CTRF Leadership Meeting March 4, 2002 Institutional Partners

Develop Infrastructure and Intellectual Property that Enhances the Competitiveness of the Partners for Clinical and Extramural Funds Principle Objective

 Evaluate gene expression (and genetic changes) in human brain, ovarian, breast and hematopoetic cancers  Link gene expression (and genetic changes) to clinical findings and clinical laboratory findings (including histopathological diagnoses) in a common database  Evaluate linked data using bioinformatics Research Objective

Funding From CTRF

CTRF Funding - Monitoring Expenses $Have identified all ledger 5 accounts $Have identified 2 of the cost share accounts $Developing format for monthly reports $Automating data acquisition remains major challenge

Reminder - Cost Share Form (VCU)

CTRF Funding - GMU

 CTRF CG Administrative Assistant (Jo Ann Breaux) is developing the mechanisms to monitor VCU ledger 5 and cost share accounts.  Plan is to create regular feedback to project PIs in future.  Cost share expenditures not paid from cost share linked ledger 4 account must be documented using ‘In Kind/3rd Party Cost Share form’ obtained from Margie Booker’s office. CTRF Funding

 Establish Focus Groups to address each of the basic tasks.  Each Focus Group to consist of professionals associated with the CTRF Project with special expertise or knowledge in one or more areas required to address basic tasks.  Structure work within Focus Groups to deal with interrelatedness of basic tasks. General Approach to Achieve Objectives

 Tissue Bank  Clinical and Pathology Laboratory Data  Database Design  Data Analysis  Quality Assurance in Microarray Analysis  (Chip Fabrication - proposed) Focus Group

Focus Group Leaders

Tissue Acquisition System (TAS) Protocol Completed Approved by MCC Protocol Review & Monitoring Comm Contents – Tissue Handling residual sample obtained after pathology review – IC - Obtain prior to & following surgery – Primary Data Collection Submitted to VCU IRB Meeting in March at INOVA to review and assist in establishment of Tissue Bank procedures Tissue Bank Staff Activities (Cynthia Losco) –Improving current tissue storage system –Meeting with pathologists and MCC faculty tissue handling breast clinic scheduler –Developing expertise at cutting frozen section and microdissection –developing database fields necessary for Tissue Bank CTRF - Tissue Bank

GMU  Test Installation of GeneX up and Running  Created And Instantiated A Schema For A Row-modeled Clinical Database  Creating A Linking Table To Span The Two Databases VCU  MCC - Cancer Registry Being Transferred to ODBC Compliant Format  MCC - Transferring Current Fox Pro to SQL 2000  Pathology Shadow DB (SQL 2000)  operational  contains AP Surg Path Reports (text)  Categorization of AP Data  identify categories (complete)  evaluate accuracy of SNOMED coding (in progress)  evaluate procedure to automate categorization from AP text reports Database Design/Clinical Info

 Developing a document to address issues related to QA/QC  Set up meetings with QA/QC Focus Group members  Identifying a ‘standard’ RNA from cultured leukemic or breast cancer cell lines to be examined by all platforms  GMU - Exploring “Terabyte” Database and associated analysis tools  VCU/GMU - GeneX database - has associated analysis tools  Set up at both institutions QA/QC Data Analysis

 Establish Standing Weekly or Biweekly Meeting Dates and Times  Complete the Milestone Updates  Document Discussions and Progress Using Listservs

 CG-TISBK: Tissue Bank  CG-CLNDT: Clinical and Pathology Data  CG-DBDSN: Database Design  CG-ANLDT: Analyze Data (Data Analysis)  CG-QAQC: QAQC  CG-LDRPI: Focus Group Leaders and PIs  CG-MEMBS: All Members Communication Amongst Members and Focus Groups

 Address messages to:  Unsubscribe to the listserv by submitting a message with the words SIGNOFF listname to:  Subscribe to the listserv by asking the PI with whom you work to submit your name and E- mail address to the Program Director (C.Garrett)  USE the listserv(s) to inform members of your activity or to seek advice from the members. LISTSERVS

Website Update  Framework for site has been started  URL is in process of being issued   Annual Report being used; more content is still needed  Will be completed by mid April

 Intellectual property reporting - licenses, patents, etc  Publications  New applications identified - CTRF Administrative office  will search for new funding opportunities (SPIN)  will collect CVs, other support, facilities, interest documents  goal million in d.c. from CTRF CG Project  Any other discoveries  Federal money leveraged  Private research money leveraged  Advancement of technology and economic development in VA CTRF - Specific Reportables

 Old Business  New Business

Monday April 1, :30 A.M.