Lymphoid System VIBS 443/602.

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Lymphoid System VIBS 443/602

OBJECTIVES PURPOSE OF THE IMMUNE SYSTEM CELLULAR BASIS OF IMMUNITY EFFECTORS OF RESPONSE INDUCTION OF THE RESPONSE ONTOGENY

FUNCTIONS OF THE IMMUNE SYSTEM PROTECTION AGAINST FOREIGN INVADERS INTO BODY PRODUCE / PROTECT GERM FREE ENVIRONMENT OF THE BODY

Thymus

123 Thymus, newborn

THYMUS RETICULUM FRAMEWORK - EPITHELIUM EPITHELIUM

116 Lymph node Afferent lymphatic duct

Lymph node follicle Germinal center Lymphocyte Reticulum cell

116 Lymph node Afferent lymphatic duct Subscapular space

Parafollicular region High endothelial cells of a venule Parafollicular region

High endothelial cells of a venule parafollicular region High endothelial cells of a venule

INDUCTION OF RESPONSE PERIPHERAL ORGAN NEEDED TO GET ANTIGEN AND RESPONSIVE CELL TO INTERACT LYMPHOCYTE RECIRCULATING APPROPRIATE CONTEXT

19754 Lymphatic sinus in lymph node

Venous sinus Medullary cord Lymphatic sinus or Medullary sinus Lymph node medulla: Reticulum cell Lymphocyte Plasma cell Medullary cord Lymphatic sinus or Medullary sinus

Lymphatic sinus or Medullary sinus Macrophages in the lymph node medulla Macrophages

Efferent lymphatic duct? 116

Spleen

Spleen (reticulum stain)- capsule and reticulum fibers 218 Spleen (reticulum stain)- capsule and reticulum fibers

122 Spleen

Spleen red and white pulp 122

Spleen: Central artery Periarteriolar lymphatic sheath Red pulp

Spleen 122 Marginal zone

Spleen 122 central artery PENICILLARY ARTERIES Marginal zone

Splenic red pulp: Venous sinus Littoral cell Billroth’s strand

Spleen reticulum: Reticulum fiber Billroth’s strand Sinuses

Litteral cells of spleenic venial Spleen #19752 (UT117)

Tonsil

419 Tonsil

Tonsil 419

Esophagus and trachea, monkey 242 Esophagus and trachea, monkey

145 Fundic stomach

Large intestine or Colon, monkey 153 Large intestine or Colon, monkey

Plasma cells large intestine in Colon, monkey 153 Plasma cells large intestine in Colon, monkey

32412

EM 6

Image 112

LIFE CYCLE OF LYMPHOCYTES FETAL ORGANS BONE MARROW PRIMARY LYMPHOID ORGANS (ANTIGEN INDEPENDENT DEVELOPMENT) - THYMUS - T LYMPHOCYTES - BONE MARROW - B LYMPHOCYTES SECONDARY LYMPHOID ORGANS (ANTIGEN DEPENDENT DEVELOPMENT) LYMPH NODES LYMPHOID NODULES SPLEEN

ONTOGENY STEM CELLS - BONE MARROW PRIMARY LYMPHOID ORGANS SECONDARY LYMPHOID ORGANS DIFFERENTIATION TO MATURE ANTIGEN – REACTIVE CELLS

thymus Bone marrow