Chapter 14 Opener State initiatives such as the 2012 Oregon Cannabis Tax Act are aimed at decriminalizing or even legalizing the possession and use of small amounts of cannabis

Figure 14.1 Poster advertising the 1936 film Reefer Madness

Figure 14.2 Cannabis plants

Figure 14.3 The potent form of cannabis called hashish

Figure 14.4 An 8000-year time line of cannabis use around the world

Figure 14.5 Chemical structure of  9 -tetrahydro-cannabinol (THC)

Figure 14.6 Mean time course of plasma THC concentrations

Figure 14.7 Autoradiogram of a horizontal section through a rat brain

Figure 14.8 Hippocampal CB 1 receptors are responsible for memory impairment

Figure 14.9 Chemical structures of the endocannabinoids anandamide and 2-arachidonoylglycerol (2-AG)

Figure Retrograde signaling by endocannabinoids

Box 14.1, Figure A CB 1 receptors are widely expressed in the neural circuitry of the human brain that regulates mood

Figure Food intake and body weight gain are reduced in rats

Figure Role of the endocannabinoid system in extinction of auditory fear conditioning

Figure Role of the endocannabinoid system in extinction of auditory fear conditioning (Part 1)

Figure Role of the endocannabinoid system in extinction of auditory fear conditioning (Part 2)

Figure Reduction in the subjective and physiological effects of smoked marijuana

Figure Time course of plasma THC concentrations

Figure Time course of plasma THC concentrations (Part 1)

Figure Time course of plasma THC concentrations (Part 2)

Figure Oral THC produces a dose-dependent impairment in explicit memory

Figure Acquisition of THC self-administration by squirrel monkeys

Figure Probability of initiating marijuana use as a function of age

Figure Trajectories of marijuana use from the adolescent period to approximately age 37

Figure Desensitization of cannabinoid receptors produced by chronic THC exposure

Figure Time course of overall withdrawal discomfort in heavy marijuana users undergoing abstinence

Figure Time course of relapse to first marijuana use after the first 30 days of treatment

Box 14.2, Figure A Increased probability of developing psychosis in heavy cannabis users