7.7 KIDNEY DISEASE Proper kidney function is necessary for homeostasis Many kidney disorders can be detected by urinalysis

Diabetes Mellitus -Caused by inadequate secretion of insulin from pancreas - If insulin is ↓ then blood sugar levels ↑ -Proximal tubule has enough ATP to reabsorb 0.1% of blood sugar back into the blood -In “DB” much higher [blood sugar] is found -Therefore excess sugar stays in nephron and increases its osmotic pressure -As a result water stays in the nephron and is later lost as urine -Individuals with “DM” urinate a lot and are often thirsty - Water lost with excreted sugar must be replenished so they drink alot

Diabetes Insipidus -Caused by destruction of hypothalamic ADH producing cells or nerve tract destruction to the pituitary -If ADH is ↓ then water reabsorption is ↓  urine output ↑ -Thirst ↑ -Individuals with “DI” must drink lots of water to replace what is lost

Bright’s Disease-Nephritis General name for kidney diseases caused by inflammation of the nephrons One type affects the glomerulus blood vessels Bacteria produce toxins which destroy theses blood vessels  nephron permeability changed Proteins and large molecules can then get into the nephron (proteins cannot be reabsorbed) Osmotic pressure in the nephron changes and large amounts of water stay in the nephron  urine ↑

KIDNEY STONES Caused by precipitation of mineral solutes from the blood Can be alkaline or acidic Calcium Oxalate - acidic –most common Calcium oxalate stones are the most common. They tend to form when the urine is acidic, meaning it has a low pH.. Dietary oxalate is an organic molecule found in many vegetables, fruits, and nuts. Calcium from bone may also play a role in kidney stone formation

Calcium Oxalate stone

Kidney stones can lodge in the renal pelvis or move into the bladder or urethra Very painful

Blasting Kidney Stones

7.6 HW