1 Imaging the Awake Animal– Positron Emission Tomography D.J.Schlyer, C.L.Woody, P.Vaska, V.Radeka, S.Stoll, P.O’Connor, J.-F. Pratte, A. Villanueva, B. Yu, R. Ferrieri, M. Schueller and N. Volkow, Brookhaven National Laboratory S.Shokouhi, A.Kriplani, S.Southekal, S.Krishnamoorthy, A.Dwivedi, Stony Brook University, Brookhaven National Lab I.I. Rampil, C. Page, D. Samaras, Y. Wang, W. Zhang II.Stony Brook University III.R. Huesman, J. Qi, G. Klein IV.Lawrence Berkeley National Lab

2 RatCAP - Rat Conscious Animal PET: Allows the effects of anesthesia to be assessed The Problem: Current small animal PET imaging instruments are limited by the need to use anesthesia which can profoundly depress brain function. The 9th International Conference: Peace through Mind/Brain Science The effect of anesthetics on the uptake of β-CFT on the dopamine transporter of the monkey brain. The effect of different anesthetics on the uptake of [ 18 F]Fluorodopa in various regions of the monkey brain. D.B. Stout et al, UCLA 1998

Timeline of Bioengineering Projects  1999 – Start detector development for measuring blood radioactivity non-invasively with BNL LDRD funding and later with a CRADA with CTI, Inc.  2000 – DOE Biomedical Engineering grant for the beta microprobe  2001 – Expand the project to include the microprobe, motion tracking and imaging the awake animal. Received DOE funding for 3 years.  2003 – first electronic chip sent for fabrication. Received two NIH (NIBIB) grants for parts of this research effort.  2004 – First prototype of the animal scanner with the ASIC in place. Extension of DOE funding.

4 RatCAP - Project Collaborations lead to valuable expertise in related fields These projects are a collaboration between several departments and divisions at BNL, SUNY Stony Brook and LBNL Weekly meetings within BNL, and telephone contact with outside collaborators

5 Biomedical Engineering Projects n RatCAP (Rat Conscious Animal PET) n Input Functions for Modeling – Wrist Scanner – Microprobe n Motion Tracking n Motion Correction n Stress assessment

6 Summary n Basics Physics and Engineering are being applied to Medical problems n The Expertise at BNL can be applied in many ways