Figure S1 Figure S1. Search results of single nucleotide polymorphism (SNP) of rs466013 of the GRIK1 gene used in this study (http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=466013).

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Presentation transcript:

Figure S1 Figure S1. Search results of single nucleotide polymorphism (SNP) of rs of the GRIK1 gene used in this study ( Above: Genomic location of rs (pointed by red arrows; the NCBI Assembly database: GRCh37.p10 version). Down: Genomic location of rs for 6 versions of the NCBI Assembly database (pointed by red arrows).

Figure S2 Figure S2. Search results of single nucleotide polymorphisms (SNPs) of rs466013, rs425507, rs and rs of the GRIK1 gene used in this study ( bin/hgTracks?db=hg18&position=chr21%3A &hgsid= _3haDCdtlwLEpPqkcmUFYdaAFYNhx). Above: Genomic location of the GRIK1 gene. Down: Genomic location of rs466013, rs425507, rs and rs (pointed by red arrows; the NCBI Assembly database: NCBI36/hg18 version).

Figure S3 Figure S3. GRIK1 mRNA expression levels in peripheral blood mononuclear cells according to the GRIK1 SNPs (rs and rs402280) genotypes. The relative GRIK1 expression was detected by quantitative real-time RT-PCR, and expression from individuals with TT+TA genotypes was compared to that from individuals with AA genotype. The GRIK1 (NM_ ) primer sequences were 5’- gcggttagagatggatcaaca-3’ (located at nucleotide of the transcript (NM_ ) and 5’-tcatgaaagcccacatcttct-3’ (located at nucleotide of the transcript (NM_ )). The relative expression levels were expressed as GRIK1 mRNA/ HPRT mRNA ratio.

Figure S4 (European) (Japanese) (Taiwanese) Common elements in "Khor CC", "Onouchi Y" and "Lee YC": rs (MIA) Common elements in "Onouchi Y" and "Lee YC": rs (BLK) rs (BLK) rs (BLK) rs (ITPKC) rs (CD40) European Asian Figure S4. Venn diagram of 4 GWAS studies. Gene SNPs from 4 GWAS studies were used for searching for common gene SNPs by using Venny website (

Figure S5 (Japanese) (Taiwanese) (Korean) Common elements in "Onouchi Y " and "Lee YC": rs (BLK) rs (BLK) rs (BLK) rs (ITPKC) rs (MIA) rs (CD40) Common elements in "Lee YC" and "Tsai FJ": rs (MRPS22) rs (MRPS22) rs (COPB2) rs (BTBD1) Asian Figure S5. Venn diagram of 4 GWAS studies. Gene SNPs from 4 GWAS studies were used for searching for common gene SNPs by using Venny website (