+ Chapter 4: Designing Studies Section 4.3b Using Studies Wisely.

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+ Chapter 4: Designing Studies Section 4.3b Using Studies Wisely

+ Section 4.3b Using Studies Wisely After this section, you should be able to… DESCRIBE the challenges of establishing causation DEFINE the scope of inference HW: pg 206: 91 – 98, 103 – 109 odd Learning Objectives

+ Using Studies Wisely Scope of Inference What type of inference can be made from a particular study? The answer depends on the design of the study. Well-designed experiments randomly assign individuals to treatment groups. However, most experiments don’t select experimental units at random from the larger population. That limits such experiments to inference about cause and effect. Observational studies don’t randomly assign individuals to groups, which rules out inference about cause and effect. Observational studies that use random sampling can makeinferences about the population.

+ Using Studies Wisely The Challenges of Establishing Causation A well-designed experiment tells us that changes in the explanatory variable cause changes in the response variable. Lack of realism can limit our ability to apply the conclusions of an experiment to the settings of greatest interest. In some cases it isn’t practical or ethical to do an experiment. Consider these questions: Does texting while driving increase the risk of having an accident?  Does going to church regularly help people live longer?  Does smoking cause lung cancer? It is sometimes possible to build a strong case for causation in the absence of experiments by considering data from observational studies.

+ Using Studies Wisely The Challenges of Establishing Causation When we can’t do an experiment, we can use the following criteria for establishing causation.  The association is strong.  The association is consistent.  Larger values of the explanatory variable are associated with stronger responses.  The alleged cause precedes the effect in time.  The alleged cause is plausible. Discuss how each of these criteria apply to the observational studies of the relationship between smoking and lung cancer.

+ Using Studies Wisely Data Ethics Complex issues of data ethics arise when we collect data from people. Here are some basic standards of data ethics that must be obeyed by all studies that gather data from humansubjects, both observational studies and experiments. All planned studies must be reviewed in advance by an institutional review board charged with protecting the safety and well-being of the subjects. All individuals who are subjects in a study must give their informed consent before data are collected. All individual data must be kept confidential. Only statistical summaries for groups of subjects may be made public. Basic Data Ethics

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