Modulation of Endogenous Osteogenic Protein-1 (OP-1) by Interleukin-1 in Adult Human Articular Cartilage by Charis Merrihew, Stephan Soeder, David C. Rueger,

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Presentation transcript:

Modulation of Endogenous Osteogenic Protein-1 (OP-1) by Interleukin-1 in Adult Human Articular Cartilage by Charis Merrihew, Stephan Soeder, David C. Rueger, Klaus E. Kuettner, and Susan Chubinskaya J Bone Joint Surg Am Volume 85(suppl 3):67-74 August 1, 2003 ©2003 by The Journal of Bone and Joint Surgery, Inc.

Levels of endogenous OP-1 (A) and proteoglycans (PG) (B) in cartilage explants cultured for twenty-five days in the presence of medium under steady-state conditions. Charis Merrihew et al. J Bone Joint Surg Am 2003;85:67-74 ©2003 by The Journal of Bone and Joint Surgery, Inc.

Representative Western blot of cartilage extracts from tissue explants cultured at a nearly steady state and blotted with anti-OP-1 antibody MAB354 under reduced conditions. Charis Merrihew et al. J Bone Joint Surg Am 2003;85:67-74 ©2003 by The Journal of Bone and Joint Surgery, Inc.

Changes in endogenous OP-1 protein induced by treatment with a low dose (0.1 ng/mL) of IL-1β. Charis Merrihew et al. J Bone Joint Surg Am 2003;85:67-74 ©2003 by The Journal of Bone and Joint Surgery, Inc.

Semiquantitative RT-PCR analysis of OP-1 mRNA expression in normal human cartilage after forty-eight and ninety-six hours of treatment with medium (cultured control) (white bars), the low dose of IL-1β (diagonally striped bars), or the high dose of IL-1β (c... Charis Merrihew et al. J Bone Joint Surg Am 2003;85:67-74 ©2003 by The Journal of Bone and Joint Surgery, Inc.

Changes in endogenous OP-1 protein induced by treatment with the high dose (1.0 ng/mL) of IL- 1β. Charis Merrihew et al. J Bone Joint Surg Am 2003;85:67-74 ©2003 by The Journal of Bone and Joint Surgery, Inc.