Syndecan-4–dependent Rac1 regulation determines directional migration in response to the extracellular matrix Mark D. Bass, Kirsty A. Roach, Mark R. Morgan, Zohreh Mostafavi-Pour, Tobias Schoen, Takashi Muramatsu, Ulrike Mayer, Christoph Ballestrem, Joachim P. Spatz, and Martin J. Humphries J. Cell Biol. Volume 177(3): May 2, 2007 © 2007 Bass et.al.

Figure 1. Engagement of syndecan-4 is essential for activation of Rac1 during adhesion to fibronectin Bass et al. J. Cell Biol. 2007:177: © 2007 Bass et.al.

Figure 2. Engagement of syndecan-4 drives the biphasic formation of adhesion complexes Bass et al. J. Cell Biol. 2007:177: © 2007 Bass et.al.

Figure 3. Engagement of syndecan-4 contributes toward but is not essential for the regulation of RhoA during adhesion to fibronectin Bass et al. J. Cell Biol. 2007:177: © 2007 Bass et.al.

Figure 4. The PKCα-binding motif of syndecan-4 mediates Rac1 regulation and adhesion complex formation Bass et al. J. Cell Biol. 2007:177: © 2007 Bass et.al.

Figure 5. PKC activity is necessary for the regulation of Rac1 and adhesion complex formation Bass et al. J. Cell Biol. 2007:177: © 2007 Bass et.al.

Figure 6. Expression of syndecan-4 determines the persistence of migration on cell-derived matrices Bass et al. J. Cell Biol. 2007:177: © 2007 Bass et.al.

Figure 7. Expression of syndecan-4 regulates the localized activity of Rac1 Bass et al. J. Cell Biol. 2007:177: © 2007 Bass et.al.

Figure 8. The PKCα-binding motif of syndecan-4 allows cells to turn in response to changes in the matrix environment Bass et al. J. Cell Biol. 2007:177: © 2007 Bass et.al.

Figure 9. Engagement of syndecan-4 determines both the direction and persistence of migration Bass et al. J. Cell Biol. 2007:177: © 2007 Bass et.al.