A. B. Supplemental Figure S1. A. B. Supplemental Figure S2.

Slides:

Advertisements

Similar presentations

Supplemental Figure 1 A No. at risk T T T

Advertisements

Fidler, I.J., Nat. Rev. Cancer (2003) Road map to cancer metastasis.

Supplement Figure 1 Pharmacokinetic profile of PF was evaluated in nude mice. Mice were treated with 1 and 10 mg/kg PF via sc and iv.

P247. Figure 9-1 p248 Figure 9-2 p251 p251 Figure 9-3 p253.

Effects of declining sorafenib levels and dose on acquired reversible resistance and toxicity in hepatocellular carcinoma Elizabeth A. Kuczynski, Christina.

Angiogenesis ↓ Metastasis. Angiogenesis--- The process of developing new blood vessels. Cancer cells (probably like all tissues) secrete substances that.

B C Supplementary Figure 1 Control X0 Control X9  -HBx (mAb)  -HBx (rabbit serum) ABCEFD aa ABCEF X0 X9 (  D) A

WEEK 1 You have 10 seconds to name…

Supplemental Table 1 Source and authentication of cell lines.

Supplementary Figure 1. The effect of 17-DMAG on the growth of lung cancer cells with Met amplification Tumor cells were continuously treated with increasing.

Fig. S1 Fig. S1. Experimental design of DSS-induced colitis (A) and AOM/DSS-induced colon carcinogenesis (B).

Cancer Chapter 4 Supplement. Cancer - important facts Cancer is uncontrolled cell growth It requires several steps to form It is very different depending.

Differential drug responses of circulating tumor cells within patient blood Andrew D. Hughes, Jocelyn R. Marshall, Eric Keller, John D. Powderly, Bryan.

Supplementary Figure S1 a

Continuous Delivery of Neutralizing Antibodies Elevate CCL2 Levels in Mice Bearing MCF10CA1d Breast Tumor Xenografts Min Yao, Curtis Smart, Qingting.

B A P-AXL P-AXL AXL AXL P-MET P-MET MET MET P-Akt-473 P-Akt-473 AKT

Copyright © 2002 American Medical Association. All rights reserved.

Anesthes. 2012;116(4): doi: /ALN.0b013e31824b9512 Figure Legend:

BET-EFF (MV-4-11): Sacrificing 4 Sick Mice – Tumor Burden

Copyright © 2013 Elsevier Inc. All rights reserved.

Drug concentration (μM)

Mouse OBK (Serial section)

A, Effect of folate-FITC (500 nmol/kg, 5 days/week) and/or sunitinib (20 mg/kg daily) therapy on the growth of M109 tumors in Balb/c mice. A, Effect of.

ONLINE SUPPLEMENTAL MATERIAL

SCC244 significantly inhibited c-Met–driven tumor growth in cancer CDX models. SCC244 significantly inhibited c-Met–driven tumor growth in cancer CDX models.

MiR-155-5p positively regulates colon cancer cell migration by targeting RhoA 2016 Molecular Biomarkers, Berlin | AMR AL-HAIDARI | Department of Clinical.

a b c d Supplemental Figure S x108 IFU 2x108 IFU 28 28

A list of 289 proteins whose detection in plasma or serum is documented in the literature “Steady-state” forms are listed, but cleavage products formed.

Slit-Robo Cancer Cell Volume 4, Issue 1, Pages 1-2 (July 2003)

MMP9 potentiates pulmonary metastasis formation

A surrogate marker to monitor angiogenesis at last

Supplementary Figure 2 Secondary transplanted brain tumors from PASC1 express human GH. Immuno-fluorescence staining of brain sections from mice implanted.

Allie Punke Pharmacokinetics Allie Punke

Figure 2 Three distinct mechanisms of activation of

1A 1B Supplementary Figure 1. Parp HT29 C-Parp Gapdh LoVo

Volume 67, Issue 2, Pages (February 2005)

Macrophage Metabolism Shapes Angiogenesis in Tumors

Gastroenterology news

Supplemental Tables/Figures

DQ661 improves survival in colon cancer model and potentiates activity of gemcitabine in KPC pancreatic cancer syngeneic model. DQ661 improves survival.

Supplementary figure1. CK7 CK20 CDX2 DPEP1 Cut off value: 85%

Supplemental Figure 1A Pt Pt Pre-treatment

Helena M. Viola et al. BTS 2018;3:

Fig. 3 M7824 inhibits tumor growth and metastasis and provides long-term antitumor immunity. M7824 inhibits tumor growth and metastasis and provides long-term.

An Integrin-Linked Machinery of Cytoskeletal Regulation that Enables Experimental Tumor Initiation and Metastatic Colonization Tsukasa Shibue, Mary W.

Supplementary Figure S4

Supp. Figure 1 MM-302 trastuzumab Vessels Hoechst Merge.

A n.s. WT 4-1BB-/- B n.s. WT 4-1BB-/-

CD8+ T cells were immunomodulated and required for the efficacy of anti–4-1BB/anti–PD-1 combination treatment. CD8+ T cells were immunomodulated and required.

Asparagine and Glutamine: Co-conspirators Fueling Metastasis

A B C D Supplementary Figure S1 UMSCC1 Plateau: 24 hr Pre-Treatment

C A B * * * * HCC1954 HCC1569 Supplementary-Figure S5 Tumor cells sc.

Fig. 3 M7824 inhibits tumor growth and metastasis and provides long-term antitumor immunity. M7824 inhibits tumor growth and metastasis and provides long-term.

Healthy volunteers (n=28) P value CRC patients 　　　　　　　 (n=30) ±9.3

The amount of PGE2 released by osteoblastic cells was greatest when the cells were treated with serum collected in the post-hibernation period (N=9). The.

Supplementary figure 1 A B Water (Control) Pre-alcohol Post-alcohol

© The Author(s) Published by Science and Education Publishing.

A schematic representation of NOTCH signaling through DAB1–ABL–TRIO–RHO that stimulates colorectal cancer invasion and metastasis. A schematic representation.

Paclitaxel treatment along with CXCR2 knockdown reduces tumor growth and metastasis. Paclitaxel treatment along with CXCR2 knockdown reduces tumor growth.

THE GROWTH ENVIRONMENT.

GM-CSF is required for CA-MSC–induced tumor metastasis.

Noninvasive detection of acquired MET amplification as a mechanism of afatinib/trastuzumab resistance using cfDNA. Noninvasive detection of acquired MET.

Comparison of in vivo activity of 4D5scFvZZ and 4D5scFv.

Serum IFNγ and immune responses following tecemotide/cisplatin combination treatment in a urethane-induced hMUC1.Tg lung cancer mouse model. Serum IFNγ.

PDL192 and inhibit the growth of xenograft tumors.

Ganetespib suppresses tumor growth and extends survival in ALK+ NSCLC xenografts. Ganetespib suppresses tumor growth and extends survival in ALK+ NSCLC.

BV6 increases bone metastasis.

CPI-444 synergizes with anti–PD-L1 and anti–CTLA-4 treatment.

Parthenolide inhibits tumor promotion and increases p21 expression in vivo. Parthenolide inhibits tumor promotion and increases p21 expression in vivo.

Presentation transcript:

A. B. Supplemental Figure S1

A. B. Supplemental Figure S2

Supplemental Figure S3

Supplementary Figure S4 A.B.C.

A. Colon26 B. Tubo.A5 Supplemental Figure S5

C. A. Serum drug levels (ug/ml) +/- SEM Dose (mg/kg) CmaxSteady state Cmin2 weeks post final dose ± ± ± ± ± ± ± ± 0.82<LLQ ± 4.98<LLQ 0.3<LLQ Supplemental Figure S6 B.

Supplementary Figure S7 B. A. C.

Supplementary Figure S8 Cytoskeletal reorganization and migration Tumor growth and metastasis APC Tumor Cells Endothelial Cells T cells Tumor Associated Macrophage Tumor Cells PLXNB1 Proteolytic cleavage by MT1-MMP Transactivation ErbB2 MET PDZ- RhoGEF/ or RhoGAP RhoA P SEMA4D 1 2