Antibody mediated hypersensitivity reaction (type II) PhD. kefah F. hassoon 2014.

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Presentation transcript:

Antibody mediated hypersensitivity reaction (type II) PhD. kefah F. hassoon 2014

Characters : ۩ Author name Cytotoxic Reactions ۩ Involve activation of complement by IgG or IgM binding to an antigenic cell.

Characteristic features Primed IgG or IgM + Antigen on membrane Injury and dysfunction of target cells

Type II hypersensitivity role of complement and phagocytes

Common disease of type II hypersensitivity 1 )HTR ( Hemolytic Transfusion Reactions) Hemolysis : mismatch of ABO blood group,severely destroy RBC.

2) Hemolytic disease of newborn (HDN) Due to Rh incompatibility. Mother Rh -, first baby Rh + (Ab), second baby Rh +, fetal RBC destroyed

Prophylaxis Inject Anti-RhD Abs mothers (immediately after delivery) Prevents sensitization

3) (ADCC) like: Drug Induced Hemolytic Anemia Occurs when an antibiotic forms a complex with red blood cell membrane protein, Induces formation of antibodies. Activation Complement. Penicillin hemolytic anemia sulphonamides thrombocytopenic purpura

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