Vein Wrapping for Chronic Nerve Constriction Injury in a Rat Model by Kenichi Murakami, Kazuki Kuniyoshi, Nahoko Iwakura, Yusuke Matsuura, Takane Suzuki,

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Nerve injury induces mechanical hypersensitivity.

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Vein Wrapping for Chronic Nerve Constriction Injury in a Rat Model by Kenichi Murakami, Kazuki Kuniyoshi, Nahoko Iwakura, Yusuke Matsuura, Takane Suzuki, Kazuhisa Takahashi, and Seiji Ohtori J Bone Joint Surg Am Volume 96(10): May 21, 2014 ©2014 by The Journal of Bone and Joint Surgery, Inc.

Rats in the control group displayed significantly greater mechanical allodynia on von Frey testing as compared with the sham group during the first four weeks postsurgery (**p < 0.01). Kenichi Murakami et al. J Bone Joint Surg Am 2014;96: ©2014 by The Journal of Bone and Joint Surgery, Inc.

On CatWalk gait analysis, the mean intensity and maximum intensity of the hind paws of rats in the control group were decreased compared with those in the sham group two weeks after surgery. Kenichi Murakami et al. J Bone Joint Surg Am 2014;96: ©2014 by The Journal of Bone and Joint Surgery, Inc.

On CatWalk gait analysis, the contact time and print area of the hind paws of rats in the control group were decreased relative to those in the sham group two weeks after surgery. Kenichi Murakami et al. J Bone Joint Surg Am 2014;96: ©2014 by The Journal of Bone and Joint Surgery, Inc.

Immunohistochemistry analysis of the L4-L5 dorsal root ganglia fourteen days after surgery. Kenichi Murakami et al. J Bone Joint Surg Am 2014;96: ©2014 by The Journal of Bone and Joint Surgery, Inc.

Nerve cross sections stained with toluidine blue at fourteen days postsurgery. Kenichi Murakami et al. J Bone Joint Surg Am 2014;96: ©2014 by The Journal of Bone and Joint Surgery, Inc.

Cross sections stained with toluidine blue five months postsurgery. Kenichi Murakami et al. J Bone Joint Surg Am 2014;96: ©2014 by The Journal of Bone and Joint Surgery, Inc.

Longitudinal sections stained with hematoxylin and eosin five months after surgery. Kenichi Murakami et al. J Bone Joint Surg Am 2014;96: ©2014 by The Journal of Bone and Joint Surgery, Inc.

Neurotrophic factor concentration in the ligated sciatic nerve was measured with use of ELISA. NGF concentration in the sciatic nerves one and three days postsurgery was significantly higher in the control (C) and vein-wrapping (V) groups than in the sham (... Kenichi Murakami et al. J Bone Joint Surg Am 2014;96: ©2014 by The Journal of Bone and Joint Surgery, Inc.