Artemisinin Artemisinin.

Slides:

Advertisements

Similar presentations

A Business Proposal and Plan

Advertisements

Student: Song Lijie Advisor: Prashant Yadav Santiago Kraiselburd

Spectacular decline of malaria on Malaita: A review of laboratory-based data Helen Polosovai BApplSc(MedLab) AAH Laboratory Dept.

Malaria The entire preview So what did we learn? Our Method: A simple technique of using questionnaires and thorough internet research Our Aim: To find.

Doctors For Life International: An NGO’s perspective on Malaria in Southern Africa Bola Omoniyi, Ph.D. http:

MALARIA A Widespread Disease.... RESEARCH PROJECT.

Addressing the analytical hurdles associated with Artemisia annua extracts Josh L Pilkington, Chris Preston and Rachel L Gomes Department of Chemical and.

THE ORIGINS OF DRUGS. Aspirin is commonly used painkiller. Now made synthetically in a lab, it has a similar chemical structure to salicylic acid extracted.

Elsevier Inc. items and derived items © 2010 by Saunders, an imprint of Elsevier Inc. Chapter 97 Antiprotozoal Drugs I: Antimalarial Agents.

DEVELOPMENT IN THE PRODUCTION AND EFFECTIVENESS OF ARTEMISININ Background Information Currently, there is an epidemic of malaria in third world countries,

Production of the Antimalarial Drug Precursor Artemisinic Acid in Engineered Yeast February 12, 2007 Patrick Gildea By J.D. Keasling et all.

Malaria  Malaria is a vector borne parasitic disease caused by the genus Plasmodium, affecting over 100 countries of the tropical and subtropical regions.

Production of an antimalarial drug in engineered S. cerevisiae

The use of Artemisia annua in the prevention of necrotic enteritis in a broiler disease model R.M. Engberg, K. Grevsen, E. Ivarsen, X. C. Fretté, L.P.

Presented to you by: Moin Patel. What type of illness is it? Malaria is a mosquito- borne infectious disease of humans and other animals.

Institute of Oncology and Radiology of Serbia In vitro study of antitumor effect of Artemisia annua tea Zorica Juranić 1, Pierre Lutgen 2, Ivana Matić.

Malaria treatment. Dr abdulrahman al shaikh.. Introduction million patients died because of malaria every year. Most deaths due to Plasmodium Falciparum.

Global warming and the need for sustainable, CO 2 - neutral sources energy.

Kim Harkins Gabby Fabby Lee Carter John Illuminati.

Malaria Drugs and Vaccines Derek Cervenka and Peter Knopick Parasitology 460/462.

Choice of antimalarial drugs Malaria Medicines & Supplies Services RBM Partnership Secretariat.

A New Treatment for Malaria: Artemisinin Prof. Dr. Talal Aburjai.

Malaria By:Emmaline Lamp Noah Wasosky Ryan Stainer Mckayla Boyd Tyler Vlaiku.

+ Some Like It Hot! Using Spices to Teach Inquiry.

Antimalarial Drug Quality in Mekong Region by Krongthong Thimasarn Coordinator RBM Mekong UN-ESCAP Bangkok Acting Regional Advisor for Malaria SEARO Prepared.

Artemisinin- an innovative cornerstone for anti- malaria therapy 성균관대학교 약학대학 천연물약품화학연구실 석박통합 7 기 김충섭.

Lesson 2. Water Quality Certain substances, such as ion, can affect the taste or color of water but are harmless unless present at very high levels. Other.

Synthetic Biology for Synthetic Drugs and Fuels Jay Keasling University of California, Berkeley Lawrence Berkeley National Laboratory.

Synthetically Engineered Artemisinin Lianne Ryan.

Silas P. Cook Education: B.A. Reed College (1999);

Chinese name: Qing hoa su English: wormwood, sweet wormwood

Synthetic Biology Project Examples

MALARIA Malaria is caused by protozoan parasites of the genus Plasmodium.

BLI Research Project By: Tiffany Hou Artemisinin.

Production of Artemisinic acid using engineered yeast Journal Club I 7 th July 09 David Roche Charles Fracchia.

Semi-synthetic Artemisinin: A New Source of Artemisinin to Reduce Barriers to ACT Access November 18, 2008 London, UK Presented By Philippe Desjeux, PhD.

Lesson 1.3 The Good Samaritans Definitions and templates for: Case Notes 1.3 Investigation Activity 1.3.

history 1 ½ y boy Fever –2 weeks –Intermittent –39.5 –Chills and rigor –sweating.

ANALYSIS ANTI-MALARIAL DRUG: COARTEM 20/120 Aaron Beck, Alexis Balgeman, John N. Gitua (Mentor) Department of Chemistry, College of Arts and Sciences Drake.

The Mode of Action and Possible Target of Artemisinin

Plants used to treat infectious disease - II Antimalarials.

Department of Kinesiology and Applied Physiology Nobel Prize in Physiology or Medicine William Campbell, Satoshi Omura "for their discoveries concerning.

Progress of Artemisinin production in East Africa Advanced Bio- Extracts Limited Lisa Amenya.

Pharmacognosy and Drug Discovery Prof. Suleiman Olimat.

Malaria treatment (References: PubMed, Google, Ginsburg H and Golenser J publications)

In this 6-minute interview, Ghosh talks about his most recent book (pub. 2015), not Calcutta Chromosome, but it will give you some idea of his personality,

Bee ethic – created by a team of Italian engineers, beekeepers and academia.

Global Health Malaria. Transmission Malaria is spread by mosquitoes carrying parasites of the Plasmodium type. Four species of Plasmodium are responsible.

Medicine By:Charles Barath. System of Medicine System of medicine is at least 23 centuries old that aims to prevent to heal disease by maintaining or.

Homework 1 Part 2. Drug Resistance and Malaria Download “Drug Resistance and Malaria” by Peter Bloland, published by the World Health Organization:

南亚和印度.

Antimalarial Drugs.

Chapter 7 Section 2 Water Quality LT: I will describe the methods humans use to monitor water quality.

Hindu College of PG Courses

ARTEMISININ DR ANTHONY MELVIN CRASTO PRINCIPAL SCIENTIST india

Table 1 Characteristics of patients at enrollment who received artesunate-amodiaquine (ASAQ) or artemether-lumefantrine (AL) for treatment of malaria.

Chemical Engineering Honors Overview

Energy Transformations

Artemisinin: Discovery from the Chinese Herbal Garden

How to Contain Artemisinin- and Multidrug-Resistant Falciparum Malaria

A New Golden Age of Natural Products Drug Discovery

MMV: Origins, Mission & Vision

Pharmacology 3 antimalarial drugs lecture 11 by Prof.Dr. Mohamed Fahmy

Chapter 15 SEction 9 How is Water Purified?

Water purification in water treatment plant.

Photosynthesis.

Chapter 15 SEction 9 How is Water Purified?

Chinese name: Qing hoa su English: wormwood, sweet wormwood

Volume 9, Issue 6, Pages (June 2016)

Presentation transcript:

Artemisinin Artemisinin

isolated from plant Artemisia annua, or sweet wormwood

History 200 BC：First recorded in the Fifty-two prescriptions found in Han Dynasty tomb

History 200 B.C.：First recorded in the Fifty-two prescriptions found in Han Dynasty tomb 340 A.D.: Application for malaria first described in The Handbook of Prescriptions for Emergencies

History 200 B.C.：First recorded in the Fifty-two prescriptions found in Han Dynasty tomb 340 A.D.: The Handbook of Prescriptions for Emergencies 1972: Tu Youyou discovered artemisinin in the leaves of Artemisia annua

Malaria Mosquito-borne disease caused by prostists of genus plasmodium

Malaria Mosquito-borne disease caused by Prostists of the genus of plasmodium Kills more than 600,000 people every year - 90% of them are children

Artemisinin and its derivatives are proofed effective against malaria caused by protist Plasmodium falciparum Artemisinin Combination Therapy (ACTs) are now standard treatment worldwide for plasmodium falciparum malaria.

HOWEVER .......

SO....... Supply of plant-derived artemisinin is highly unstable $1-2.5/treatment. People in developing world cannot afford the treatments SO.......

A stable source of affordable artemisinin is required.

In 2006, Prossfer Jay D Keasling and his team reported that they had engineered Saccharomyces cerevisiae yeast to produce small amount of artemisinic acid which is the precursor of artemisinin and can be purified and chemically converted into artemisnin.

Current Process Artemisinin Purification Chemical Conversion Artemisia Annua Chemical Conversion Artemether Arteether Artesunate Artelinate

Microbial Process Purification Chemical Conversion Artemisinin Acid Purification Saccharomyces cerevisiae Chemical Conversion Artemether Arteether Artesunate Artelinate

References http://i00.c.aliimg.com/img/ibank/2011/548/121/373121845_873535556.jpg http://i00.i.aliimg.com/photo/v0/392737864/Sweet_Wormwood_Oil.jpg http://k.mengxiang.org/uploads/201205/1338259472ve23vDLh.jpg http://res.news.ifeng.com/dci_2011/0920/re_4e783a52d5a0f.jpg http://www.malariaconsortium.org/wide-banner/153.jpg http://media.npr.org/assets/img/2011/04/25/mosquito-48fc799e70f6892f5c6708a44bfde3a63681f80b-s6-c30.jpg http://en.wikipedia.org/wiki/Artemisinin http://www.iom.edu/~/media/Files/Activity%20Files/PublicHealth/MicrobialThreats/2011-MAR-14/Keasling%2003%2015%2011.pdf https://upload.wikimedia.org/wikipedia/commons/thumb/f/f1/Malaria.jpg/230px-Malaria.jpg http://www.lbl.gov/Science-Articles/Archive/assets/images/2004/Mar-24/Keasling.jpg http://disinfecto.com/images/artesunate.jpg http://www.chm.bris.ac.uk/motm/artemisinin/artemisinic-acid.gif