BY:DR ISRAA OMAR

 Both are synthetic agents  Work by inhibition of plasminogen activation  They are orally active  A potential side effect of treatment is intravascular thrombosis

 It stops bleeding by blocking plasmin  It can inhibit streptokinase  It is used to reduce blood loss in patients undergoing cardiopulmonary bypass surgery  Side effect include anaphylactic reaction if there is previous exposure within 12 month, renal dysfunction is also reported with the use of this drug

 Antagonizes the anticoagulant effect of heparin  It is derived from fish sperm and testes and has a high content of arginine which make it basic drug  It is positive charge neutralize the negative charge of heparin thus making a stable complex and prevent the action of heparin  Side effect include dyspnea, flushing, hypotension and bradycardia especially when injected rapidly

 It antagonize the action of oral anticoagulant  The action of vitamin k start after 24 hours ;thus,if immediate action is required,fresh frozen plasma should be infused

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