Ionotropic & Metabotropic Receptors Lesson 12. Membrane Proteins: Ionophores n Ion Channels n Non-gated l always open n Gated l chemically-gated l electrically-gated.

Slides:



Advertisements
Similar presentations
Chapter 11 Cell Communication
Advertisements

Structure and gating mechanism of the acetylcholine receptor pore.
Neuronal Transmission
Molecular Targets For Drug Action (syllabus - prof.Kršiak) FOUR MAJOR TARGETS FOR DRUGS: 1. RECEPTORS 2. ION CHANNELS 3. CARRIER MOLECULES 4. ENZYMES.
A signal ___________________ pathway is a series of steps by which a signal on a cell’s surface is _______________into a specific cellular ______________.
1 Cell-Cell Interactions Chapter 7. 2 Outline Cell Signaling Receptor Proteins – Intracellular Receptors – Cell Surface Receptors Initiating the Intracellular.
Receptors and transduction mechanisms II Chapter 12 –The Neuron by Levitan and Kacsmarek.
Biology 107 Cellular Communication October 7, 2002.
1 Session 5 The Neuron II: Synaptic Transmission PS111: Brain & Behaviour Module 1: Psychobiology.
CHAPTER 11 cell signaling
The 3 Steps.  Intracellular Receptors ◦ Proteins in the cytoplasm or in the nucleus ◦ Example: transcription factors  Receptors in the Plasma Membrane.
Receptors Lesson 8. Ligands & Receptors n Ligand l neurotransmitters l drugs n Receptor proteins l ligand binds to multiple receptors l receptor subtypes.
Biology for Engineers: Cellular and Systems Neurophysiology Christopher Fiorillo BiS 521, Fall , Part 5: Neurotransmitters,
Neural Signaling: The Membrane Potential Lesson 9.
Synaptic Transmission Lesson 12. Synapses n Communication b/n neurons n Electrical l Electrotonic conduction n Chemical l Ligand / receptor ~
1 Physiology Exam 1 Study Chapter 6 Communication & homeostasis.
Neurotransmitters Lecture 13.
Molecular Targets For Drug Action (syllabus -prof.Kršiak) FOUR MAJOR TARGETS FOR DRUGS: 1. RECEPTORS 2. ION CHANNELS 3. CARRIER MOLECULES 4. ENZYMES.
Chapter 11: Cell Communication
Neurotransmitters & Receptors Lecture 10. Ligands & Receptors n Ligand l Neurotransmitters (NT) & Drugs n Receptor proteins l Control ion channels n NT.
Cell Signaling basics.
University of Jordan1 Receptors Functions and Signal Transduction- L3 Faisal I. Mohammed, MD, PhD.
Copyright © 2010 Pearson Education, Inc. Neurotransmitter Actions Direct action Neurotransmitter binds to channel-linked receptor and opens ion channels.
Signal Transduction Lecture 14. Ligands & Receptors n Ligand l Neurotransmitters & drugs n Receptor proteins l ligand binds to multiple receptors n Binding.
AP Biology Chapter 11 Cell Communication. AP Biology The Cellular “Internet”  Within multicellular organisms, cells must communicate with one another.
(1)Graded potentials on the post-synaptic membrane: depolarization and hyperpolarization; ligand-gated mechanisms (2) What happens at a synapse? A.  Transmitter.
Cell Signaling Cells communicate in various ways. – The type of communication used by each cell is based on the type of information that needs to be passed.
Presynaptic Axon Terminal Postsynaptic Membrane Terminal Button Dendritic Spine.
Cell Communication.
Midterm 1 Need: ID, Pen, Pencil 25 multiple-choice (50%) –Ch 1,3 2/3 essays (50%) – SQ 1-12.
The Membrane Plays a Key Role in a Cell’s Response to Environmental Signals Cells can respond to many signals if they have a specific receptor.
You Must Know  3 stages of cell communication Reception, transduction, & response  How G-protein-coupled receptors receive cell signals & start transduction.
Chapter 11 Cell Communication. Cell communication signal cells communicate by direct contact or by secreting local regulators ex: growth factors, neurotransmitters.
Cell to Cell Communication
Nucleus Dendrites Collect electrical signals Cell body Integrates incoming signals and generates outgoing signal to axon Axon Passes electrical signals.
B Chapter 11~ Cell Communication. Signal-transduction pathway I b Def: Process by which a signal on a cell’s surface is converted into a specific cellular.
Intracellular Signal Transduction Pathways and Cascades.
Cell to cell communication in the nervous system The synapse Electrical synapse Chemical synapse Role of calcium “neurocrines” Receptors Post-synaptic.
Chapter 11 RQ 1. What is a type of “local signaling” for cells? 2. What is communicated through “long distance” signaling? 3. What is the first stage.
Pharmacodynamics III Receptor Families
2E2 – Timing and coordination of physiological events are regulated by multiple mechanisms. 3B2 – A variety of intercellular and intracellular signal transmissions.
ION CHANNELS AS DRUG TARGETS & CONTROL OF RECEPTOR EXPRESSION
Animal Cell Chromatin.
Ch. 14 Part 6 Cell Signaling.
An Introduction to Medicinal Chemistry 3/e PROTEINS AS DRUG TARGETS:
Cell Communication Part II
Chapter 11 – Cell Communication
Cell Communication Review
Cell Signaling Chapter 15.
SIGNAL TRANSDUCTION Signal Transduction Pathway Protein Modification Phosphorylation Cascade Protein Kinases.
Animal Cell Chromatin.
Cell Signaling.
Chapter 11 Cell Communication
Synaptic Transmission
Signal Transduction Dr. Nasim.
Neuron Physiology.
2 primary cell types in nervous system
Introduction to CNS pharmacology
RECEPTOR “ A receptor is a macromolecular component of a cell or organism that interacts with a drug and initiates the chain of biochemical events leading.
Cell Communication CHAPTER 11.
An Introduction to Medicinal Chemistry 3/e PROTEINS AS DRUG TARGETS:
Animal Cell Cell Membrane.
Signal Transduction Lecture 14. Ligands & Receptors n Ligand l Neurotransmitters & drugs n Receptor proteins l ligand binds to multiple receptors n Binding.
Drug-Receptor Interactions
Voltage-gated ion channels   Transmembrane ion channels regulated by changes in membrane potential
Cell Communication.
Neurons & Glia Lecture 5.
Cell to cell communication in the nervous system
Presentation transcript:

Ionotropic & Metabotropic Receptors Lesson 12

Membrane Proteins: Ionophores n Ion Channels n Non-gated l always open n Gated l chemically-gated l electrically-gated l mechanically-gated ~

Chemically-Gated Channels n Ligand-Receptor binding n Ligand l neurotransmitters l drugs n Receptor proteins l ligand binds to multiple receptors l receptor subtypes l specificity ~

Ligand-Receptors Binding n Binding site l specific point of ligand & receptor n Affinity l attraction l physical & electrical fit n NT or drug binds to receptor l  or  activity of neuron l excite or inhibit n Drugs mimic or block NT message ~

Lock & Key Model n Receptor changes shape n Excitation or Inhibition? l Determined by nature of receptor n NOT NT ~ n NT binds to receptor l NT = key l Receptor = lock

Receptor Subtypes n Specificity n Same NT l Binds to many receptor subtypes l Produce different effects l EPSP or IPSP n All NT systems l Several subtypes each l Drug side effects ~

Receptor A NT n ligand binds to receptor l activation: EPSP or IPSP ~

Receptor B Receptor A n Same NT can bind to different -R l different part of NT ~ NT

Receptor B Receptor A n Same NT can bind to different -R l different part of NT ~ NT

Receptor B Receptor A n Same NT can bind to different -R l different part of NT ~ NT

Ionotropic receptors n Ligand-gated channels l Ion channels n NT directly controls channel l fast action l transient ~

Metabotropic Receptors n Requires energy l GTP l Neuromodulation n G protein-gated Ion Channels l Receptor indirectly controls channel l relatively fast, but slower than ionotropic ~

G protein-gated Ion Channels R G GDP

G protein-gated Ion Channels R G GTP

G protein-gated Ion Channels R G GTP Pore

Metabotropic receptors: 2d messenger systems n 2d messenger systems l Effects relatively slow l long-lasting l Signal amplification n Effects l Control channel l Alter properties of receptors l regulation of gene expression ~

2d Messenger Systems n Signal amplification l 1 NT  activate enzyme  l ATP  1000s cAMP  10,000s  l cAMP  10,000s phosphates ~

2d Messenger Systems Receptor trans- ducer primary effector external signal: nt 2d messenger secondary effector Receptor trans- ducer primary effector external signal: nt 2d messenger secondary effector n External signal l NT = 1st messenger n Membrane-associated components l Receptor l Transducer l Primary effector n Intracellular l 2d messenger l Secondary effector ~

2d Messenger Systems R G GTP GDP * Secondary Effector Primary Effector Enzyme

2d Messenger Systems R G GTP Secondary Effector Primary Effector Enzyme

2d Messenger Systems R G GTP ATP cAMP Secondary Effector Primary Effector Enzyme

2d Messenger Systems R G GTP ATP cAMP P Secondary Effector Primary Effector Enzyme

2d Messenger Systems R G GTP ATP P Pore cAMP Secondary Effector Primary Effector Enzyme

Feedback: Privacy Policy Feedback
Do Not Sell My Personal Information
About project: SlidePlayer Terms of Service

© 2025 SlidePlayer.com. Inc. All rights reserved.