Role of Apoptosis in Pseudomonas aeruginosa Pneumonia by Richard S. Hotchkiss, W. Michael Dunne, Paul E. Swanson, Christopher G. Davis, Kevin W. Tinsley,

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Role of Apoptosis in Pseudomonas aeruginosa Pneumonia by Richard S. Hotchkiss, W. Michael Dunne, Paul E. Swanson, Christopher G. Davis, Kevin W. Tinsley, Katherine C. Chang, Timothy G. Buchman, and Irene E. Karl Science Volume 294(5548):1783a-1783 November 30, 2001 Published by AAAS

Figure 1 (A) Electron micrograph of ciliated bronchial epithelial cells from saline-treated mouse (sham), demonstrating normal morphology. Richard S. Hotchkiss et al. Science 2001;294:1783a-1783 Published by AAAS

Figure 11 TEM photomicrographs (14) of lung tissue. Richard S. Hotchkiss et al. Science 2001;294:1783a-1783 Published by AAAS

Figure 12 Monoclonal antibody test for single-stranded DNA (15) in (A) cells from uninfected mice, (B) cells from mice infected with early P. aeruginosa grown to early mid-logarithmic phase, and (C) cells from mice infected with plateau phase–grown bacteria. Richard S. Hotchkiss et al. Science 2001;294:1783a-1783 Published by AAAS

Figure 13 FACS and fluorescence microscopy (20) confirm that only logarithmic-grown P. aeruginosa trigger apoptosis of more than 90% of WI-38 cells after 60 min of infection. Richard S. Hotchkiss et al. Science 2001;294:1783a-1783 Published by AAAS

Figure 14 Internalization of P. aeruginosa by epithelial cells depends on bacterial growth conditions (21). Richard S. Hotchkiss et al. Science 2001;294:1783a-1783 Published by AAAS

Figure 2 (A) Two capillary endothelial cells (arrows, upper left portion of photomicrograph) are positive for active caspase 3 and have secondary morphologic changes consistent with apoptosis. Richard S. Hotchkiss et al. Science 2001;294:1783a-1783 Published by AAAS

Figure 3 Lung tissue obtained 24 hours after intratracheal injection and evaluated by TUNEL method. Richard S. Hotchkiss et al. Science 2001;294:1783a-1783 Published by AAAS

Figure 4 Thymi obtained 24 hours after intratracheal injection in (A) saline-treated (sham) and (B) bacterial-treated (pneumonia) mice. Richard S. Hotchkiss et al. Science 2001;294:1783a-1783 Published by AAAS