Neurotransmitter Release. High voltage Low voltage.

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Presentation transcript:

Neurotransmitter Release

High voltage Low voltage

Mechanism of Exocytosis synapsins anchor vesicle to cytoskeleton  Ca 2+ influx  activates Ca 2+ /calmodulin dependent kinase (CaMK)  phosporylaton of synapsin I  release of vesicle from cytoskeleton  move to active zone  Rab3A binds to vesicle  hydrolysis of Rab GTP to GDP + PO 4  targeted to docking site at active zone  interaction of v-SNARES and t-SNARES  docking and membrane fusion  exocytosis and release of Rab into cytoplasm t-SNARES = syntaxin and SNAP25 v-SNARE = synaptobrevin (VAMP)

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