Drill: Draw & name 5 isomers of C 3 H 5 NO. Important Amines.

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Presentation transcript:

Drill: Draw & name 5 isomers of C 3 H 5 NO

Important Amines

Amino Acids NH 2 O R C C H OH

Glycine NH 2 O H C C H OH

Alanine NH 2 O H 3 C C C H OH

Phenylalanine H 2 N O -CH 2 -CH-C-OH

Phenylalanine is changed to tyrosine by the enzyme phenylalanine oxidase (hydroxylase)

Tyrosine H 2 N O -CH 2 -CH-C-OH HO

Excess phenylalanine is broken down by amine removal to phenylpyruvic acid

Phenylpyruvic Acid O O -CH 2 -C-C-OH

Neurotransmitters Transmit chemical signals in the synapse between nerve cells as well as other places

Phenol OH

Catachol OH

Catacholamine H 2 N R OH OH

A large number of neurotransmitters are derivatives of catacholamine

Phenylalanine H 2 N O -CH 2 -CH-C-OH

Tyrosine H 2 N O -CH 2 -CH-C-OH HO

l -DOPA H 2 N O -CH 2 -CH-C-OH HO

Dopamine -CH 2 -CH 2 -NH 2 HO

Norepinephrine OH -CH-CH 2 -NH 2 HO

Epinephrine OH CH 3 -CH-CH 2 -N H HO

Amphetamine 1-phenyl-2-propylamine CH 3 -CH 2 -CH-NH 2 Upper

Methylamphetamine CH 3 CH 3 -CH 2 -CH-NH Upper

Seratonin HO N CH 2 -CH 2 -NH 2 H

Ephedrine OH CH 3 -CH 2 -CH 2 -NH 2 Decongestant

Neosynephrine OH CH 3 -CH-CH 2 -N H Decongestant HO

Draw & Name 5 isomers of: C 3 H 7 NO

Histamine NN H CH 2 -CH 2 -NH 2

Benadryl CH 3 - CH-O-CH 2 -CH 2 -N CH 3 Antihistamine

Barbiturates

Barbituric Acid O O O N N H H

Add Na to get Sodium Barbiturate O O O N: -1 N Na +1 H

Barbital O O O N N H H

Phenobarbital O O O N N H H

Alkaloids

Tropane N CH 3

Cocaine N CH 3 O O O O

Opiates

Morphine O HOOH N CH 3

Isoprene Terpenes

Myrcene 10 carbons

Terpenes 5 C - isoprene 10 C – myrceneBO 15 C – farneseneCit 30 C – squalene SLO 40 C – lycopenePP

Cyclopentanophenanthrene Steroids

Cholestane

HO Cholesterol

Lab: Today Review: Tuesday Test: Thursday

Drill: Draw & Name 5 isomers of: C 3 H 7 NO

Test Review

Know Common Amines, Amides, & Nitriles

Amine production

Predict All for Rxns in Base: Isopropyl iodide + ammonia Phenyl bromide + methylamine 1-iodobutane + diethylamine

Amide production

Predict All For: Acetic acid + ammonia Formic acid + ethylamine Benzoic acid + dimethylamine

Nitrile production

Predict all for the dehydration of: Benzoamide Propanoamide

Hydrolysis Synthesis of: Esters & Amines

Hydrolysis of: Amides & Nitriles

Predict all for the hydrolysis of: 3-phenylpropanoamide octanoamide

Aminolysis Rxns

Predict all for the aminolysis of: Phenylformate Aceticbutanoic anhydride

Know general neurotransmitters

ORGANIC HW For Monday: Work 1 – 20 on the Final Review