Development of the KIGS Model for Predicting Growth Response to Growth Hormone Replacement Therapy in Children with Idiopathic Growth Hormone Deficiency.

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Presentation transcript:

Development of the KIGS Model for Predicting Growth Response to Growth Hormone Replacement Therapy in Children with Idiopathic Growth Hormone Deficiency from Start of Treatment until Final Height KIGS 10 Year Book, 1999 Michael B Ranke, Anders Lindberg, Pierre Chatelain, Patrick Wilton, Wayne Cutfield, Kerstin Albertsson-Wikland and David A Price

M B Ranke - KIGS 10 Year Book, 1999 Selection criteria for the 593 children used to construct a prepubertal growth prediction model

(1/3) M B Ranke - KIGS 10 Year Book, 1999 Characteristics (at the beginning of their GH replacement therapy) and growth responses of a cohort of prepubertal patients with idiopathic GHD a a First year: n=593; second year: n=573; third year: n=335; fourth year: n=180. b (n=330), c (n=181), d (n=94)

M B Ranke - KIGS 10 Year Book, 1999 (2/3) Characteristics (at the beginning of their GH replacement therapy) and growth responses of a cohort of prepubertal patients with idiopathic GHD a a First year: n=593; second year: n=573; third year: n=335; fourth year: n=180. b (n=330), c (n=181), d (n=94)

M B Ranke - KIGS 10 Year Book, 1999 (3/3) Characteristics (at the beginning of their GH replacement therapy) and growth responses of a cohort of prepubertal patients with idiopathic GHD a a First year: n=593; second year: n=573; third year: n=335; fourth year: n=180. b (n=330), c (n=181), d (n=94)

M B Ranke - KIGS 10 Year Book, 1999 Regression equations for prediction of height velocity over the first year of GH replacement therapy

M B Ranke - KIGS 10 Year Book, 1999 Regression equations for prediction of height velocity during the second-fourth years of GH replacement therapy

M B Ranke - KIGS 10 Year Book, 1999 Differences between two growth prediction models in predicted height gain after the first year of GH therapy in 593 prepubertal children with idiopathic GHD

M B Ranke - KIGS 10 Year Book, 1999 Growth responses to GH therapy during puberty of 195 children with idiopathic GHD a a Values shown are medians. Data from Ranke et al (1997) b Average catch-up growth during puberty expressed as a percentage of the difference between target height and height at the onset of puberty c Average catch-up growth from the start of GH therapy to the end of puberty expressed as a percentage of the total expected growth *p<0.001 vs spontaneous puberty