Malignant diseases of the bone marrow Tornóci László Semmelweis University Institute of Pathophysiology.

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Malignant diseases of the bone marrow Tornóci László Semmelweis University Institute of Pathophysiology

Malignancies granulocytic, monocytic, erythroid, megakaryocytic MyeloidLymphoid malignant lymphomas REAL classification

Classification of myeloid malignancies Chronic myeloproliferative diseases Myelodysplastic syndromes Acute myeloid leukemias FAB (old)WHO (new) Chronic myeloproliferative diseases Myelodysplastic/myeloproliferative diseases Myelodysplastic syndromes Acute myeloid leukemias

Chronic myeloproliferative diseases CML Ph+ and Ph- Chronic idiopathic myelofibrosis Polycythemia vera Essential thrombocytemia FAB (old)WHO (new) CML Ph+ Chronic neutrophilic leukemia Chronic eosinophilic leukemia/hypereosinophilic syndrome Chronic idiopathic myelofibrosis Polycythemia vera Essential thrombocytemia

Myelodysplastic/myeloproliferative diseases none FAB (old)WHO (new) Atypical myelogenous leukemia (aCML) Chronic myelomonocytic leukemia (CMML) Juvenile myelomonocytic leukemia (JMML)

Myelodysplastic syndromes Refractory anemia (RA) Refractory anemia with ringed sideroblasts (RARS) Refractory anemia with excess blasts (RAEB) Refractory anemia with excess blasts in transformation (RAEB-T) Chronic myelomonocytic leukemia (CMML) FAB (old)WHO (new) Refractory anemia with ringed sideroblasts (FAB: RARS) without ringed sideroblasts (FAB: RA) Refractory cytopenia with multilineage dysplasia (new) Refractory anemia with excess blasts (FAB: RAEB) 5q- syndrome (new) unclassifiable (new)

Acute myeloid leukemias M0: minimally differentiated M1: myeloblastic leukemia without maturation M2: myeloblastic leukemia with maturation M3: hypergranular promyelocytic leukemia M4: myelomonocytic leukemia M4Eo: variant, increase in marrow eosinophils M5: monocytic leukemia M6: erythroleukemia (DiGuglielmo's disease) M7: megakaryoblastic leukemia FAB (old)WHO (new) AML with recurrent cytogenetic translocations AML with multilineage dysplasia AML with myelodysplastic syndrome, therapy related AML not otherwise categorized (Outlined only!)