Arginine dependence of acute myeloid leukemia blast proliferation: a novel therapeutic target by Francis Mussai, Sharon Egan, Joseph Higginbotham-Jones, Tracey Perry, Andrew Beggs, Elena Odintsova, Justin Loke, Guy Pratt, Kin Pong U, Anthony Lo, Margaret Ng, Pamela Kearns, Paul Cheng, and Carmela De Santo Blood Volume 125(15): April 9, 2015 ©2015 by American Society of Hematology

AML blasts are auxotrophic for arginine. Francis Mussai et al. Blood 2015;125: ©2015 by American Society of Hematology

BCT-100 arginine depletion reduces the number of viable AML blasts in vitro and in vivo. Francis Mussai et al. Blood 2015;125: ©2015 by American Society of Hematology

BCT-100 is cytotoxic against primary blasts from patients. Francis Mussai et al. Blood 2015;125: ©2015 by American Society of Hematology

BCT-100 depletes arginine intracellularly. Francis Mussai et al. Blood 2015;125: ©2015 by American Society of Hematology

BCT-100 halts proliferation and cell cycle arrest. Francis Mussai et al. Blood 2015;125: ©2015 by American Society of Hematology

BCT-100 induced cell cycle arrest leads to necrotic cell death. Francis Mussai et al. Blood 2015;125: ©2015 by American Society of Hematology