10 0 1 2 3 4 0 1 2 3 4 59% Ter119 CD71 10 0 1 2 3 4 0 1 2 3 4 13% 10 0 1 2 3 4 0 1 2 3 4 1.5% +/+ki/ki 10 0 1 2 3 4 0 20 40 60 80 100 2.71 10 0 1 2 3 4.

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% Ter119 CD % % +/+ki/ki Thiazole orange % max % A B PBMC Figure S8 1 (HCT: 43.3)2 (HCT: 40.8)3 (HCT: 20.8)(HCT: 49.7)

BM spleen Ter119 CD71 C n.d AAD % max D +/+ ki/ki Figure S8

Figure S BasE ProE Ter119 CD71 +/+ki/ki A BasE ProE BasE ProE PI # Cells B C /+ki/+ki/ki %CD71+, 7AAD+ cells /+ki/+ki/ki %CD71+, AnnexinV+, 7AAD- cells

+/+ +/ki ki/ki spleenBM spleen BM +/++/kiki/ki pi staining cell number Figure S10 +/+ +/ki ki/ki N4N8N16N32N+ percentage *

Figure S11 bone marrow basophilic erythroblasts GATA-1/FOG-1 activatedGATA-1/FOG-1 repressed Kit MycLyl1 GATA-2 fold change * +/+ ki/ki ** +/+ ki/ki