Molecular Genetics Structure of DNA
Phoebus Levene (1920’s) identified the 3 components of DNA molecule –deoxyribose sugars –phosphate groups –nitrogenous bases 4 nitrogenous bases identified by 1949
Erwin Chargaff (1949) isolated DNA from different organisms and measured levels of each of the 4 nitrogenous bases amt. of adenine = amt. of thymine amt. of cytosine = amt. of guanine
Rosalind Franklin produced X-ray diffraction images of DNA that suggested its double helix shape diameter 2nm, one turn 3.4nm See animation: Franklin-s-X-ray-diffraction- explanation-of-X-ray-pattern-.html Franklin-s-X-ray-diffraction- explanation-of-X-ray-pattern-.html
James Watson & Francis Crick (1952) used information from Chargaff and Franklin’s work proposed a model of DNA with a double helix of 2 anti-parallel strands won the Nobel Prize in 1962 (with Maurice Wilkins) for deducing the structure of DNA
Structure of DNA Review of 1.5 p.45-46
Nucleic Acids polymers of nucleotides: 5 carbon sugar (ribose or deoxy-) nitrogenous base C 1 phosphate group C 5
RNA vs DNA
DNA & RNA Directionality