Increased Toll-Like Receptor Activity in Patients With Metabolic Syndrome Featured Article: Ishwarlal Jialal, M.D., Ph.D., Beverley A. Huet, Ph.D., Harmeet.

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Increased Toll-Like Receptor Activity in Patients With Metabolic Syndrome Featured Article: Ishwarlal Jialal, M.D., Ph.D., Beverley A. Huet, Ph.D., Harmeet Kaur, Ph.D., Alexander Chien, B.S., Sridevi Devaraj, Ph.D. Diabetes Care Volume 35: April, 2012

Study Objective Metabolic syndrome (MetS) is a proinflammatory state, but there is a paucity of data on cellular inflammation in MetS Toll-like receptors (TLRs) are classical pattern recognition receptors of the innate immune response Aim of study was to compare monocyte TLR2 and TLR4 between MetS patients and control subjects Jialal I et al. Diabetes Care 2012;35:

Study Design Fasting blood obtained for TLR expression and activity Participants with MetS but no CVD or diabetes compared to control participants Jialal I et al. Diabetes Care 2012;35:

Conclusions Both TLR2 and TLR4 expression and activity are increased in the monocytes of patients with MetS This could contribute to increased risk for diabetes and CVD with MetS Jialal I et al. Diabetes Care 2012;35: