THE MARBURG-VIRUS animal-borne RNA virus filovirus family causes Marburg haemorrhagic fever (MHF) a form of viral hemorrhagic fever Marburg-Virus (MARV)

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Presentation transcript:

THE MARBURG-VIRUS

animal-borne RNA virus filovirus family causes Marburg haemorrhagic fever (MHF) a form of viral hemorrhagic fever Marburg-Virus (MARV)

History First outbreak in Germany 1967 Work with grivet monkeys from uganda to produce vaccines against polio 29 infections – 7 deaths

Transmitted from animal host -> human Fruit bats & african green monkeys Afterwards person-to-person contact Transmission

YearCountryVirus subtypeCasesDeaths Case fatality rate 2008 Netherland Marburg11100% (ex-Uganda) 2008 USA Marburg100% (ex-Uganda) 2007UgandaMarburg4250% 2005AngolaMarburg % 1998 to 2000DRCMarburg % 1987KenyaMarburg11100% 1980KenyaMarburg2150% 1975South AfricaMarburg3133% 1967YugoslaviaMarburg200% 1967GermanyMarburg29724% Table: Chronology of major Marburg Haemorrhagic Fever outbreaks.

Signs & Symptoms Incubation period ~ 5-10 days starts with:fever/chills/headache/myalgia rashes in thoracic/abdominal region nausea/vomiting/abdominal pain/ diarrhea Chest pain/ sore throat Increasingly severe symptops: jaundice/pancreatitis/delirium/massiv hemorrhaging/multi- organ dysfunction

Treatment & Vaccines No specific treatment for MHF Sever cases require supportive care Vaccines are currently tested with success but not available yet

Sources en/ en/ marburg-eine-stadt-sucht-einen-moerder html marburg-eine-stadt-sucht-einen-moerder html tion.html