Respiratory practical II

Slides:

Advertisements

Similar presentations

Neoplasia II: Tumor Characteristics

Advertisements

SOFT TISSUE TUMORS Prof Hesham Saad.

Neoplasia Nomenclature

Neoplasia 1: Introduction. terminology oncology: the study of tumors neoplasia: new growth (indicates autonomy with a loss of response to growth controls)

Introduction to Neoplasia

A significant increase in the incidence of endometrial cancer. This increased incidence of endometrial cancer has been widely interpreted to be a result.

Neoplasms of Lung and Pleura Dr. Raid Jastania. Lung Neoplasms Neoplasm: –new growth –Monoclonal proliferation –Genetic defect in genes controlling growth.

1. TUBERCULOSIS 2. CANCER OF THE LUNG SECOND PRACTICAL Respiratory Block Pathology Dept. KSU.

Tumors of the lung Carcinoma 90-95% Carcinoid 5 %

Adrenal Tumors. Adrenal Cortical Adenoma * Etiology: Most cases are sporadic. Association with MEN I syndrome can occur. * Signs and symptoms: Most adrenal.

Thyroid: Adenoma Lab 7, Case 1.

NEOPLASIA (Malignant Tumors)

Part 10B: Histopathology of small cell lung cancer Prepared By Bronchoscopy International Contact us at BRONCHATLAS ©

Chapter 4 Essential Concepts in Molecular Pathology Companion site for Molecular Pathology Author: William B. Coleman and Gregory J. Tsongalis.

Pathology of Neoplasia. Neoplasia Shashi-Aug-15 Introduction:  Inflammatory, Degenerative & Neoplastic  Growth – Increase in size due to synthesis of.

Section 2 Atypia.

Lung Capillary lumen Type I pneumocyte Type I pneumocyte

A 75 y/o woman with Solitary hypo function cold nodule of upper pole of right lobe.

Neoplasia p.1 SYLLABUS: RBP(Robbins Basic Pathology) Chapter: Neoplasia Definitions Nomenclature Characteristics of benign and malignant neoplasms Epidemiology.

Differentials. INFLAMMATORY Pulmonary Tuberculosis History of cough Chest X-ray findings (+) PPD test.

Pathology Lap Pictures and Explanation POD II BLOCK Abdullah Al Garni.

Respiratory practical block Pathology practical I and II Dr Shaesta Naseem Zaidi.

Revision respiratory practical block. A closer view of the lobar pneumonia demonstrates the distinct difference between the upper lobe and the consolidated.

RENAL TUMORS Renal BlockPathology Dept, KSU Renal Practical III.

Path 822: Experimental Cancer Diagnostics & Therapeutics: PATHOLOGY OF TUMOURS Sandip SenGupta, M.D. Professor of Pathology September 2005.

TUMORS OF THE LUNG * Classification: 1. Benign tumors: - Papilloma. - Fibroma. - Chondroma. 2. Locally malignant tumors: - Bronchial carcinoid 3. Malignant.

Case Study 26 Craig Horbinski, M.D., Ph.D.. The patient is a 79-year-old female with expressive aphasia for the past three to four days. Past medical.

Diagnostics. HEMATOLOGY Laboratory Work-Up NormalJune 23, 2010Remarks WBC4-11 x 10 9 /L8.08 x 10 9 /LNORMAL RBC4-6 x 10 9 /L4.82 x 10 9 /LNORMAL.

Male Genital Tract 1, Case 3 A 72-year-old man presents with back pain. On physical exam there is tenderness over the lower spine. Neurologic exam is normal.

Integrated practical Dr Shaesta Naseem

Malignant Epithelial Tumors

Diagnostic Challenge Pathology for Neurosurgery & Neurology Residents Department of Pathology University of Oklahoma Health Sciences Center, Oklahoma City,

Oral squamous cell carcinoma. A malignancy of epithelial cells Oral and oropharyngeal SCC represent about 3% of cancers in men and 2% of cancers in women.

Lung Neoplasm  Lungs frequently are the site of metastases from cancers arising in extrathoracic organs. Primary lung cancer is also a common disease.

KCP 775 신촌 세브란스 병원 R3 차윤진. 병력 63 세 남자 3 개월간의 기침, 가래, 보행시 호흡곤란 Chest CT – 우폐 중엽에 다수의 종괴.

KCP-771 ( 제출자 ) 원자력병원 R3 허일영. History  71 세 여자환자  6 개월 전부터 운동시 호흡곤란  2 주일 전부터 호흡곤란이 악화  흉부단순촬영에서 오른쪽 폐에 흉수와 무기폐.

KCP 750 경북대학교병원 병리학교실 R3 김미선. History 63 세 여자환자 8 년전에 왼쪽 골반 통증으로 내원 -> 흉부전산화단층 촬영 : 양측 폐에 10 개정 도의 작은 결절 작년에 오른쪽 어깨와 등의 통증으로 내원 -> 흉부전산화단층 촬영에서 양측 폐의.

NEOPLASIA Dr. Manal Maher Hussein.

Neoplasia Basics, Grading and Staging Kimiko Suzue MD, Ph.D. Department of Pathology Mt. Sinai Hospital.

인하대병원 전공의 최창환. Clinical history  33 세, 남자  좌측 경부 콩알크기 종괴 (1 개월전 )  U/S: 좌측 level I, II, III, IV 에 커진 림프절 ( 최 대 3.1cm)  결핵성 림프절염 혹은 비특이적 림프절염 의 심하.

KCP-786 KCP-786 서울대학교 병원 전공의 백해운. History 59 세 (Gravida5, Para2) 2007 년 HPV18(+) 이후 자궁질 도말검사를 수 차례 받음 Op Hx : 2011 년 담낭결석, 2010 년 복압 요실금 기타 특이사항 없음 2012.

KCP 748 (P ) 고려대학교 구로병원 서울대학교 병원 R4 김효진 대한세포병리학회 4 월 월례집담회.

Diseases of the prostate Osvaldo Rubinstein, MD. Normal urinary bladder with right and left ureters.

세포 월례집담회 KCP-811 전남대병원 전공의 나종인. Patient history CNUH /M C/C: 우측 경부 종물 (6-7 개월 전 ) 2 년 전 심장판막 수술 간경변 치료 중.

The tumor appears as a fairly well circumscribed, pale, fleshy, homogeneous mass Seminoma of the testis.

KCP 774 경북대학교병원 병리과 전공의 박보은. M/28 좌측 전 종격동에 약 5.6 cm 크기의 종괴 좌측 폐문부와 하엽, 중엽에도 결절 두꺼워진 엽간격막 좌측 두정엽에 부종과 출혈을 동반한 병변 α fetoprotein 20,051.0 ng/ml, CEA 7.5.

Gross and Microscopic findings Lorenzo, Jemuh, Anton.

Clinical presentation of parotid gland tumors

KCP 791 삼성서울병원 전공의 신유주. Patient history F/58 On chemotherapy (due to breast cancer) Carotid doppler ultrasound (follow up) –Thyroid nodule Ultrasonography.

KCP-780 울산대학교 서울아산병원 전공의 노진. Patient History 72/M 경부 종괴 양측 갑상선 –2.0cm, 1.5cm 석회화를 동반한 저음영의 종괴 – 다양한 크기의 여러 결절 양측 경부 level Ⅲ, Ⅳ, Ⅴ 림프절 비대.

KCP-815 서울대학교 병원 전공의 최은오.

Pulmonary hamartoma Here are two examples of a benign lung neoplasm known as a pulmonary hamartoma. These uncommon lesions appear on chest radiograph as.

CHARACTERISTICS OF BENIGN AND MALIGNANT TUMORS

JOSEPH T. SOBOTA, M.D., RICHARD J. REED, M.D. Diseases of the Chest

RESPIRATORY SYSTEM BLOCK

CLASSIFICATION OF TUMORS

NEOPLASIA (Malignant Tumors)

Finger like projections, lined by several layers of benign looking squamous cells , with central fibrovascular core Diagnosis: squamous cell papilloma.

Finger like projections,, with central fibrovascular core covered by several layers of benign looking squamous cells Diagnosis: squamous cell papilloma.

Neoplasia practice section II

The most common origin of cervical squamous cell carcinoma

Cytopathology-8 DR. MAHA AL-SEDIK.

Thickening of intima (atherosclerotic plaque) due to proliferation of cholesterol-containing macrophages and other cells Thrombus formed due to atherosclerotic.

Surgical experience of primary salivary gland tumors of lung: A case series Durgatosh Pandey, Pankaj Kumar Garg, Ashish Jakhetiya, Rambha Pandey, Sandeep.

Part 10C: Histopathology of small cell lung cancer

(A–C) Electron microscopic images obtained from two different cases, (A) a cluster of large malignant cells with cytoplasmic mucin vacuoles consistent.

Bronchial Oncocytoma With High 18F-Fluorodeoxyglucose Uptake Revealed by Nephrotic Syndrome Giovanni Leuzzi, MD, Alfredo Cesario, MD, Marco Chiappetta,

Malignant neoplasms of the mouse lung.

Presentation transcript:

Respiratory practical II 11-2-13

TWO TYPES of lung carcinoma NON-SMALL CELL CARCINOMA SQUAMOUS CELL CARCINOMA ADENOCARCINOMA LARGE CELL CARCINOMA SMALL CELL CARCINOMA The NON-small cell cancers behave and are treated similarly, the SMALL cell carcinomas are WORSE than the non-small cell carcinomas, but respond better to chemotherapy, often drastically!

SYSTEMIC effects of LUNG CANCER (PARA-NEOPLASTIC SYNDROMES)~ 5% ADH (hyponatremia) ACTH (Cushing) PTH (Hyper-CA) CALCITONIN (Hypo-CA) GONADOTROPINS SEROTONIN/BRADYKININ Any one of the histologic types of tumours may occasionally produce any one of the hormones, but tumours that produce ACTH and ADH are predominantly small cell carcinomas, whereas those that produce hypercalcemia (PTH) are mostly sqamous cell carcinomas .

7-Squamous cell carcinoma of the lung

The classical squamous cell carcinoma starting in a large bronchus centrally, with bronchial obstruction. Adenocarcinomas tend to be more peripheral and sometimes associated with scar

Malignant squamous cells , keratin , mitoses , pleomorphism Sqamous cell carcinoma may produce hypercalcemia by the secretion of PTH.

Lympho-vascular invasion

Squamous cell carcinoma of the lung: Section of the lung shows one small bronchus and tumour masses: Tumour consists of trabeculate and sheets of moderately differentiated squamous cells with little connective tissue stroma. Neoplastic squamous cells show pleomorphism, hyperchromasia, individual cell keratinization, mitoses and areas of necrosis. Peribronchial and perivascular lymphatics are occluded by tumour cells.

8-Adenocarcinoma of the lung

Adenocarcinoma, CT image

Adenocarcinoma

Adenocarcinoma

Adenocarcinoma, microscopic

Adenocarcinoma Section of the tumour shows moderately differentiated malignant glands lined by pleomorphic and hyperchromatic malignant cells showing conspicuous nucleoli . Note the presence of tissue desmoplasia around the neoplastic glands .

9-Small cell carcinoma of the lung

Small-cell carcinoma, microscopic

Small cell carcinoma . Section of the tumor shows clusters of malignant cells which are small , round , oval or spindle shaped with prominent nuclear molding , finely granular nuclear chromatin (salt and pepper pattern ) , high mitotic count.

10-Metastatic tumors of the lung

METASTATIC TUMORS LUNG is the MOST COMMON site for all metastatic tumors, regardless of site of origin It is the site of FIRST CHOICE for metastatic sarcomas for purely anatomic reasons!

Metastases Here are larger but still variably-sized nodules of metastatic carcinoma in lung Here are larger but still variably-sized nodules of metastatic carcinoma in lung