Research Aspects. Research Aspects. 1Microarrays cDNAgDNACpGDNA uRNA probesOligonucleotideantibody 2Bioinformatics Databasealgorithmsoftware Combined gene.

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Presentation transcript:

Research Aspects. Research Aspects. 1Microarrays cDNAgDNACpGDNA uRNA probesOligonucleotideantibody 2Bioinformatics Databasealgorithmsoftware Combined gene expression and product function data mining Combined gene expression and product function pathways and networks 3Translational Research and Biomarkers Malignant melanoma (Diagnostic biomarkers) Breast cancer (Diagnostic biomarkers) Gastroesophagus cancer (Therapeutic biomarkers in response to treatment using Traditional Chinese herbal medicine) 4Tumor suppressor genes Cx43 and LMSG1 Genomics and Biology of Cancer Yan A. Su, M.D., Ph.D., GWUMC

Hs Genome: 3 x 10 9 bp (3,021,400,000; Build 35.1) 85,793 unigene clusters (27,92 mRNAs B#199) Example 1 - Microarrays Oligo: Expression, Mutation cDNA: Exp. Amplificat. Deletion gDNA: Amplification, Deletion CpGDNA: DNA-Methyl, DNA-Prot  RNA: Regulatory RNA Antibody: Prot Expression Database and Bioinformatics Example 2 Random Retrovirus Insertion & Specific Growth Selection

Local Maximum Clustering Methods for Microarray Gene Expression Data Analysis 8 software for data analysis 12 databases of human and mouse genes 25 different microarrays

1.Whole genome microarray for hypothesis generation 2.Focused microarray for hypothesis test 3.Specific microarray for diagnosis Diagnostic Gene Sets 1. ER + & good pro. 2. ERBB2 - & node - 4. ER + & invasive 5. ERBB2 + & met.