Suppl. Figure 1 APP23 + X Terc +/- Terc +/-, APP23 + X Terc +/- G1Terc -/-, APP23 + X G1Terc -/- G2Terc -/-, APP23 + X G2Terc -/- G3Terc -/-, APP23 + and.

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Suppl. Figure 1 APP23 + X Terc +/- Terc +/-, APP23 + X Terc +/- G1Terc -/-, APP23 + X G1Terc -/- G2Terc -/-, APP23 + X G2Terc -/- G3Terc -/-, APP23 + and G3Terc -/-, APP23 -

Suppl. Figure 2 A B C BACE-1 GAPDH Terc +/+, APP23 + G3Terc -/-, APP23 + Presenilin-2 GAPDH Terc +/+, APP23 + G3Terc -/-, APP23 + Presenilin-1 βActin Terc +/+, APP23 + G3Terc -/-, APP23 + Terc +/+, APP23 + βActin APP G3Terc -/-, APP23 + D E APP Expression (Relative to GAPDH) G3Terc -/- APP23 + Terc +/+ APP23 + P=0.5784

Suppl. Figure 3 A B CD Terc +/+, APP23 - G3Terc -/-, APP23 - Terc +/+, APP23 + G3Terc -/-, APP23 + C AB D

B DAPIIba1-FITC BrdU-Cy3Overlay Suppl. Figure BrdU/Iba-1 Positive Cells /Vision Field (Cortex) G3Terc -/- APP23 - Terc +/+ APP23 - P= A

Suppl. Figure 5 A C B Iba-1 Positive Cells /Unit Plaque Area G3Terc -/- APP23 + Terc +/+ APP G3Terc -/- APP23 + Terc +/+ APP mRNA Expression (Relative to GAPDH) G3Terc -/-, APP23 - Terc +/+, APP23 - TGF-beta IL1-beta CXCL TNF-alpha IL CCL5 CCL MHCII MHCII mRNA Expression (Relative to GAPDH) P= P=0.5727

Suppl. Figure Number of Astrocytes at Plaques Vicinity G3Terc -/- APP23 + Terc +/+ APP23 + P=0.7365

Suppl. Table 1 Primer NameSequence Il1-beta For 5´-TGT AAT GAA AGA CGG CAC ACC-3´ Il1-beta Rev 5´-TCT TCT TTG GGT ATT GCT TGG-3´ Il6 For 5'-GTC ACC AAA CTG GAT ATA ATC AGG-3´ Il6 Rev 5´-CCA GGT AGC TAT GGT ACT CCA GAA-3´ CCL2 For 5´-TTC AGT CTG GTA ACA TGA CGG-3´ CCL2 Rev 5´-GGT GCG TTG AGT CTG GCA TAA-3´ CCL5 For 5´-ACA CAC TTG GCG GTT CCT TC-3´ CCL5 Rev 5´-TGC TCC AAT CTT GCA GTC GT-3´ TGF-beta For 5´-TGG AGC TGG TGA AAC GGA AG-3´ TGF-beta Rev 5´-ACA GGA TCT GGC CAC GGA T-3´ TNF-alpha For 5´-TGC CTA TGT CCT CTT C-3´ TNF-alpha Rev 5´-GAG GCC ATT TAC TTC T-3´ CXCL10 For 5´-GCT CGC AGG GAT GAT TTC AA-3´ CXCL10 Rev 5´-GGG CCA GTG AGA ATG AGG G-3´ MHCII For 5'-CCA GTA ACC CCT CCT CAC ATC-3´ MHCII Rev 5'-TCC TAC AGG CTG CTG ACA AG-3´