CIRRHOSISPathophysiology&Complications. Normal liver functions Carbohydrate Metabolism Hypo- or hyperglycemia Fatty Acids Metabolism Lipid Transport.

Slides:

Advertisements

Similar presentations

Acute Liver Failure.

Advertisements

Hepatocirrhosis Liver cirrhosis.

Infectious hepatitis Clinical manifestations: Asymptomatic Acute Chronic Asymptomatic carrier Hepatic failure Cirrhosis Hepatocellular carcinoma.

H4 Functions of the liver

HEPATIC FAILURE TITO A. GALLA. HEALTHY LIVER LIVER FUNCTION  METABOLISM  DETOXIFICATION PROCESS  PROTEIN SYNTHESIS  MANUFACTURE OF CLOTTING FACTOR.

Dr. David Pearson Gastroenterology, Victoria.  None relevant to this presentation.

Chronic Liver Disease Simon Lynes. Definition Progressive destruction and regeneration of the liver parenchyma leading to fibrosis and cirrhosis.

Anesthesia and Liver Disease E.A. Steele, MD May 4, 2005.

Cirrhosis of the Liver. Hepatic Cirrhosis It is a chronic progressive disease characterized by: - replacement of normal liver tissue with diffuse fibrosis.

Cirrhosis Biol E-163 TA session 1/8/06. Cirrhosis Fibrosis (accumulation of connective tissue) that progresses to cirrhosis Replacement of liver tissue.

Identify the organ. 2. Identify the organ. 3. What is causing the “striped” pattern in organ #2? 4. Name one organ in the abdomen that is intraperitoneal.

Rebuttals Due Wednesday May 30 th Please follow rebuttal protocol as outlined in the syllabus.

CLINICAL CHEMISTRY-2 (MLT 302) LIVER FUNCTION AND THE BILIARY TRACT LECTURE FIVE Dr. Essam H. Aljiffri.

The Liver. Function: –Metabolism Anatomy/Histology –Right, left lobe –Biliary Tree –Components of Liver: 1. Liver Parenchyma (lobule) 2. Portal area (vessels,

Metabolism FOOD proteins sugars fats amino acids fatty acids simple sugars (glucose) muscle proteins liver glycogen fat lipids glucose.

1 CLINICAL CHEMISTRY-2 (MLT 302) LIVER FUNCTION AND THE BILIARY TRACT LECTURE ONE Dr. Essam H. Aljiffri.

Gastrointestinal Pathophysiology II Pancreas and Liver Nancy Long Sieber Ph.D. December 13, 2010.

Liver carbohydrate metabolism lipid metabolism protein & AA metabolism synthesis of plasma proteins vitamin metabolism digestion (bile synthesis) detoxification.

Complications of Liver Cirrhosis Ayman Abdo MD, AmBIM, FRCPC.

Cirrhosis of the Liver Kayla Shoaf.

Liver pathology: CIRRHOSIS

Chronic hepatitis in childhood Modes of presentation Acute onset jaundice and persisting Gradual development of signs of liver disease Asymptomatic finding.

Liver Cirrhosis S. Diana Garcia

Severe Paediatric Liver Conditions Acute liver failure Reye syndrome “Impila poisoning” Ascites Chronic liver disease Chronic hepatitis Hepatic schistosomiasis.

Metabolic diseases of the liver Central role in metabolism Causes and mechanisms of dysfunction Clinical patterns of metabolic disease Clinical approach.

Liver disease Prepared by: Siti Norhaiza Bt Hadzir.

CIRRHOSISPathophysiology&Complications. What is Cirrhosis?

CIRRHOSIS OF LIVER PORTAL HYPERTENSION HEPATIC ENCHEPALOPATHY

Hormones. Hormones: compounds which are synthesized and secreted from special secretory or endocrine glands.

 Hepatic Pathology and Respiratory System Topics in Human Pathophysiology Fall 2011 Gilead Drug Safety and Public Health.

Cirrhosis. * Definition: Chronic, diffuse, irreversible disorder of the liver characterized by loss of the normal liver architecture and replacement by.

Adult Medical- Surgical Nursing Gastro-intestinal Module: Liver Cirrhosis.

Copyright © 2007, 2004, 2000, Mosby, Inc., an affiliate of Elsevier Inc. All Rights Reserved. Chapter 44 Nursing Management Liver, Pancreas, and Biliary.

Liver Function Tests. Tests Based on Detoxification and Excretory Functions.

LIVER CIRRHOSIS LIVER CIRRHOSIS. THE ANATOMY OF THE PORTAL VENOUS SYSTEM.

Cirrhosis 18 November 2009 Thomas C Sodeman MD Associate Professor of Medicine Chief, Division of Gastroenterology.

Evaluating the Patient With Abnormal Liver Tests-2 פרופ ' צבי אקרמן מבית חולים הדסה הר הצופים.

INTERFERENCE TO NUTRITIONAL NEEDS DUE TO DEGENERATION AND INFLAMMATION Cirrhosis and Hepatitis.

INCIDENTAL FINDINGS Joel Thompson, MSIII November 19, 2008.

CIRRHOSIS DR.AMANULLAH ABBASI FCPS, MRCP SENIOR REGISTRAR WARD-7 JPMC.

Cirrhosis Dr. Meg-angela Christi M. Amores. Cirrhosis a histopathologically defined condition – pathologic features consist of the development of fibrosis.

Assist. Prof. Mona Arafa Tropical Medicine Department

Adult Medical- Surgical Nursing Gastro-intestinal Module: Jaundice.

Hepatobiliary system Integrated practical

C IRRHOSIS. A LCOHOLIC L IVER I NJURY : Alcoholic Liver disease - Patterns Fatty change, Acute hepatitis Chronic hepatitis Cirrhosis, Chronic Liver failure.

A 57-year-old man presents with fatigue for several months. He underwent a blood transfusion with several units in 1982 after car accident. Physical examination.

LIVER PHYSIOLOGY & PATHOPHYSIOLOGY TILLY ADAMSON HELEN TURNBULL-ROSS.

Complications of Liver Cirrhosis

Cirrhoses And Its Complications Ahmad Shavakhi.MD Associate professor of gastroenterology.

Option H4 Function of the Liver. H.4.1 Outline the circulation of blood through liver tissue, including the hepatic artery, hepatic portal vein, sinusoids.

Gilead -Topics in Human Pathophysiology Fall 2009 Drug Safety and Public Health.

The Liver Anatomy Largest gland in the body (1.5 kg) Under the diaphragm, within the rib cage in the upper right quadrant of the abdomen Only human organ.

Liver dysfunction and Drugs metabolism Dr V.Sebghatollahi Isfahan university of medical science.

The liver and its diseases

Definition  Is a chronic disease characterized by scaring and necrotic tissue replaced by fibrotic tissue. Resulting in hepatic insufficiency and portal.

Lab (2): Liver Function profile (LFT)

Alcohol related Liver Disease

Dr. Abdulwahhab S. Abdullah CABM, FICMS-G&H

Lab (2): Liver Function profile (LFT)

The Accessory organs: Pancreas and liver

Dr. Abdulwahhab S. Abdullah CABM, FICMS-G&H

GENERAL MEDICINE (VCM 401)

Cirrhosis Key features:

Orthotopic liver transplant, recurrent non-alcoholic steatohepatitis

Alcoholic foamy degeneration with early alcoholic cirrhosis

Job of assistant 1: Pancreas

Option H4 Function of the Liver.

Option H4 Function of the Liver.

LIVER CIRRHOSIS IN PSC: DIAGNOSIS AND MANAGEMENT

Presentation transcript:

CIRRHOSISPathophysiology&Complications

Normal liver functions Carbohydrate Metabolism Hypo- or hyperglycemia Fatty Acids Metabolism Lipid Transport Hyper- or hypolipidemia Proteins Metabolism Serum Albumin Vitamin K–Dependent Blood Coagulation Proteins Bilirubin Metabolism Bile Production Fat-Soluble Vitamins Detoxification Drugs and hormones Providing continual source of energy for entire body Regulation of storage and modulate availability of systemic nutrients Subject to hormonal modulation by endocrine organs (Pancreas, adrenal gland, and thyroid, neuronal regulation)

What is Cirrhosis?

Definition: Nodular formation Hepatic necrosis and degeneration combined with hepatic regeneration and fibrosis leading to Nodular formation Cirrhosis

What is patophysiology of Cirrhosis?

Causes (Etiology of chronic necrosis) +Host (Liver reaction) Lead to Cirrhosis & complications Cirrhosis

What is clinical manifestation of Cirrhosis?

Clinical manifestations: - No symptoms (routine examination) 40% - Impaired hepatocellular function (Liver failure) - Portal hypertension - Clinical manifestation of underlying disease Cirrhosis

How do you make diagnosis of cirrhosis?

Diagnostic approach: 1.Liver function tests (PT, Pr., Alb, Bili, PLT) 2.Liver damage tests (AST>ALT, Alk.Ph) 3.Liver ultrasound (nodularity, decrease in size, portal vein enlargment, prominent left lobe) 4.Etiological diagnostic tests 5.Liver biopsy 6.Surveillance tests (AFP, sonography, endoscopy, pracentesis, creatinine) Cirrhosis

What is natural history of Cirrhosis?

What is general clinical management of cirrhosis?

Clinical management: 1.Etiological treatment 2.Prophylactic treatment 3.Pre-transplantation care 4.Liver transplantation Cirrhosis

How do you screen for EVs?

Ascites

SBP

Encephalopathy

Hepatorenal syndrome