This is what would happen under the myelin sheath. At the end of the myelin sheath, the membrane potential would still be above.

Slides:

Advertisements

Similar presentations

Cell Signaling A. Types of Cell Signaling

Advertisements

CELL TO CELL COMMUNICATION Part 2. Transduction: Cascades relay signals Signal transduction involves multiple steps Multistep pathways can amplify a signal.

CELL COMMUNICATION. YOU MUST KNOW… THE 3 STAGES OF CELL COMMUNICATION: RECEPTION, TRANSDUCTION, AND RESPONSE HOW G-PROTEIN-COUPLED RECEPTORS RECEIVE CELL.

Lecture 2, Oct 11 Important points from 10/7:

Receptors & Signaling. Assumed Knowledge Structure of membrane proteins Ion concentrations across membranes Second messengers in signal transduction Regulation.

Signal Transmission & Gene Expression AKA – Cell Signaling Basics (we will revisit this topic during body systems)

Cell Signaling.

Hydrophilic signal molecules Hydrophilic signal moleculespeptide hormones neurotransmitters Hydrophilic signal molecules such as peptide hormones and neurotransmitters.

Dr Amena Rahim Biochemistry Types of Receptors. Domains present on the receptors All receptors have two functional domains: 1. Recognition domain 2. Coupling.

Signal transmission and signal transduction Xia Qiang, PhD Department of Physiology Rm C518, Block C, Research Building, School of Medicine Tel:

Ion Channels. Cell membrane Voltage-gated Ion Channels voltage-gated because they open and close depending on the electrical potential across the membrane.

Biological Hierarchy:

Signal Pathways in Eukaryotic Cells Overview. Lipid Soluble Hormones.

CELL RECEPTORS AND SIGNALLING By Phil and Alex. Basics Signalling controls all aspects of cell behaviour: Growth Differentiation Metabolism 3 main types.

Second Messengers and Signal Transduction

Signal transmission and signal transduction XIA Qiang, MD & PhD Department of Physiology Room 518, Block C, Research Building School of Medicine, Zijingang.

B. Signal Transduction Pathway (cell signaling)

Cell Signaling & Communication. Cellular Signaling cells respond to various types of signals signals provide information about a cell’s environment.

Chapter 6-10 AP Biology. Define phagocytosis and pinocytosis. What does it mean for a cell to have a concentration gradient?

Three Stages The process in which a signal on the outside of a cell is turned in to a specific cellular response on the inside of a cell is called a signal.

Chapter 15 Baboon text Cell Signaling and Communication 15.1 What Are Signals, and How Do Cells Respond to Them? Cells receive signals from 1. Physical.

How Do Water Soluble (Protein Based) Hormones Work?

Seven-Transmembrane Receptor Signaling Heterotrimeric G-proteins & Second Messenger Pathways.

CHAPTER 13 Insulin Signaling. Figure 13.1 – General mechanism of signal transduction across a membrane Steps involved: 1. Release of primary messenger.

University of Jordan1 Receptors Functions and Signal Transduction- L3 Faisal I. Mohammed, MD, PhD.

Mekanisme Kerja Hormon

Cell to Cell Communication

Cell Communication.

Cell Signaling How to Get a Message from the outside of the Cell to the inside of the cell.

11.3 Transduction: Cascades of molecular interactions relay signals from receptors to target molecules in the cell  Signal transduction usually involves.

Chapter  Differentiate between the following:  Paracrine  Endocrine  Autocrine.

Mechanism of action of hormones acting on cell surface By Dr. Umar M.T.

The Endocrine System: Hormones and Gene Expression Samuel Yang Henok Daniel 4/3/13.

Chapter 11 RQ 1. What is a type of “local signaling” for cells? 2. What is communicated through “long distance” signaling? 3. What is the first stage.

瞧！我们是舞那姿样如的此自优信美！诺贝尔阿尔弗雷德 · 贝恩哈德 · 诺贝尔 (Alfred ) 生于瑞典的斯德哥尔摩。一生致力于炸药的研究，因发明硝化甘油引爆剂、硝化甘油固体炸药和胶状炸药等，被誉为 “ 炸药大王 ” 。他不仅从事理论研究，而且进行工业实.

Cascading………. Can greatly amplify the signal to numerous molecules at each step *usually involves “phosphorylating” proteins a)protein kinase – transfers.

Introduction to Receptors

Pharmacodynamics III Receptor Families

3.D.3 Signal Transduction Signal transduction pathways link signal reception with cellular response.

Signal transmission and signal transduction

Ch. 14 Part 6 Cell Signaling.

Cellular Signaling Ch. 11.

Cell Communication Part II

Chapter 15 Baboon text Cell Signaling and Communication 15

Signals and Responses Cell Communication.

Cell Signaling Chapter 15.

SIGNAL TRANSDUCTION Signal Transduction Pathway Protein Modification Phosphorylation Cascade Protein Kinases.

Ch Membrane Potential 6.5 Cell Signaling

Cell to Cell Communication via G-Protein Linked Receptors

Cell Communication.

Cell Communication (Signaling) Part 2

Cell Communication (Signaling) Part 2

Cell Signaling.

Intracellular Receptors

Eric Niederhoffer SIU-SOM

Cell Communication AP Biology.

Receiving and responding to messages

Cell Communication (Signaling) Part 2

Cell to Cell Communication via G-Protein Linked Receptors

Lipid Soluble Hormone.

Cell Communication CHAPTER 11.

Chapter 11~ Cell Communication

Chapter 11 Cell Communication.

Cell Communication (Signaling) Part 2

Specific signal transduction mechanisms

Function introduction to G proteins (more details in another lecture)

Chapter 11 A. Cell Signals Cell signaling has evolved over time

Review Quiz Please open this review in a slide show mode. Answer a question first, then go to the next slide for the correct answer.

Presentation transcript:

This is what would happen under the myelin sheath. At the end of the myelin sheath, the membrane potential would still be above threshold, and the action potential would be regenerated.

1994 Nobel Prize in Medicine Alfred G. GilmanMartin Rodbell

(1) Resting state (2) Receptor activates G protein (3) Alpha sub-unit separates and has action on amplifier (4) Alpha sub-unit breaks off of amplifier and recombines with other sub-units

A first messenger (1) binds to a specific receptor (2) The transducer (3), a G protein – composed of alpha-, beta- and gamma subunits – is activated This stimulates the amplifier (4), adenylate cyclase, which produces (5) the second messenger, cyclic AMP, from (6) ATP (adenosine triphosphate) (7) A cascade of enzymatic reactions alters the behavior of the cell and (8) via phosphorylation, an ion channel (11) is opened. Note: ignore (9) and (10) A specific example of how a G-protein activates cAMP