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Medical Immunology 医学免疫学 Li Yi ( 李一 ) Professor, Director of Ph D 教授、博士生导师 Department of Immunology 免疫学教研室

Today  Study of immunology**  Overview of immunology***

Study of immunology** （一） 免疫学基本理论部分： 20 学时。 语言：以英文授课为主、中文总结为辅。 教材：采用国外英文教材为主、中文教材为辅。 授课方式 : 自讲与讲授两种相结合； 考试方式： 50 分（闭卷考试）。 笔试（或口试）中英文必答、中文必答和中英文选答相结合。 （二） 免疫学研究进展部分： 20 学时。 语言：以中文授课为主。 授课方式： “ 以研究专题为中心 ” 。 考试方式： 50 分（开卷考试）。撰写综述。

沉浸式双语教学 (immersion program) 过渡式双语教学 (transitional bilingual education) 保留性双语教学 (maintenance bilingual education) 教学模式确立 双语教学

Approach to study of immunology I. Study by yourself (Homework) II. Presentation in class III. Summary

Groups I.9 study groups are needed (4-5 persons/group). II.Study with your group partners (Homework). III.Talk by one member of your group in class. IV. Summary by teacher.

免疫学基本理论部分： -- 50’ Presentation: 5’ Test: 45’

Presentation Evaluation Criteria 1. Presented or explained content clearly Emphasized important points Summarized or reviewed major points Used graphics or visual aids or other enhancements to support presentation Used appropriate voice volume and inflection. 10

IMMUNOLOGY ???

Let’s start with questions

Question-1 Our environment contains a great variety of infectious microbes, why could we keep healthy?

Question-2 What should we do before transplanting blood ---- Transfusion ?

Questions Why do we need to do gene matching before transplantation ? 2. Why is it very difficult to find perfect donor for recipient in transplantation ?

Question-4  Do you have any experience about allergy?  What is the allergy?

Question-5 1. What is vaccine ? 2. How do vaccines work?

Questions ？ Answer ！ Immunology

Immune System Pathology of IS Functions of IS Applications

Overview of Immunology Organs and tissues Cells Molecules Components of IS Functions of IS Pathology of IR * IS: Immune system IR: Immune response Applications Prevention Diagnosis Therapy Antigen (Ag) Immune Responses Control mechanisms Hypersensitivity Autoimmune disease Immunodeficiency Tumor Transplantation rejection

Functions of Immune System Immunological defense Immunological homeostasis Immunological surveillance

Immunological defense: The immune system protects us from attack by microbes and worms. Functions of Immune System -1

Immunological homeostasis : The immune system could eliminate the inflammatory or died self-cells. Functions of Immune System -2

Immunological surveillance: The immune system could destroy the tumor cells and protects us from clinical tumor formation. Functions of Immune System -3 Tumorcell Tumorcell Tumorcell Tumorcell Tumorcell Tumorcell Tumorcell

Overview of Immunology Organs and tissues Cells Molecules Components of IS Functions of IS Pathology of IR * IS: Immune system IR: Immune response Applications Prevention Diagnosis Therapy Antigen (Ag) Immune Responses Control mechanisms Hypersensitivity Autoimmune disease Immunodeficiency Tumor Transplantation rejection

Immune Responses Ag Organs and tissues Cells Molecules  Immunologic defense  Immunologic homeostasis  Immunologic surveillance  Hypersensitivity  Immunodeficiency  Autoimmune diseases  Tumor  Transplantation rejection IR

 Organs and tissues  Cells  Molecules Components of immune system

— Primary lymphoid organs Bone Marrow Thymus — Secondary lymphoid organs Lymph nodes Spleen Mucosa-associated lymphoid tissues (MALT) Organs and Tissues of Immune System Components of IS -1

Cells of Immune System Components of IS -2

TH: T help cells TH1 TH2 TC: T cytotoxic cells, CTL Classes of T cells

Cells of Immune System Phagocytes: Cells of mononuclear phagocyte system Neutrophils (Polymorphonuclear neutrophils, PMN) Auxiliary cells Basophiles (mast cells) Cytotoxic cells Tc (CTLs) NK cells Eosinophils

— Antibody (Ab) — Complement (C) — Cytokines (CK) — Major Histocompatibility Complex (MHC) Molecules of Immune System Components of IS -3

Overview of Immunology Organs and tissues Cells Molecules Components of IS Functions of IS Pathology of IR * IS: Immune system IR: Immune response Applications Prevention Diagnosis Therapy Antigen (Ag) Immune Responses Control mechanisms Hypersensitivity Autoimmune disease Immunodeficiency Tumor Transplantation rejection

Functions of Immune System Antigen (Ag) Immune Responses (IR) Control mechanisms See:

Ag DCs Th1 Tc B Ab PMN NK Th2 Complement Immune Response (IR) Targetcells MHCCK MHCCK CKs CKs

Types of Immune Response  Innate immunity (Natural immunity)  Adaptive immunity (Acquired immunity)

Innate and Adaptive Immunity Innate immunity Adaptive immunity CellsMq/DCs T and B cells Granulocytes NK cells MoleculesCytokines Antibodies Complement Characteristics Responds rapidly Slow to start No specificity Highly specificity No memory Memory

Overview of Immunology Organs and tissues Cells Molecules － Antibodies － Complement － Cytokines － MHC Components of IS Functions of IS Pathology of IR * IS: Immune system IR: Immune response Applications Prevention Diagnosis Therapy Antigen (Ag) Immune Responses Control mechanisms Hypersensitivity Autoimmune disease Immunodeficiency Tumor Transplantation rejection

HYPERSENSITIVITY The immune system “overreacts ” to antigen function disorder or tissue damage

Types of hypersensitivity Type I: Allergy or immediate Type II:Cytotoxic Type III:Immune complex Type IV:Cell mediated or delayed Type I: Allergy or immediate Type II:Cytotoxic Type III:Immune complex Type IV:Cell mediated or delayed Different ?? Mechanisms !!

Autoimmune disease (AD) Mq T B Self Self-Ag Immune Immune system response system response TissueDamage AbComplement CKs

DCs Th1 Tc B Ab PMN NK Th2 Complement Immune Response (IR) Targetcells MHCCK MHCCK CKs CKs Tumorcell

Tumor escape from surveillanceTumorcell Immunesystem Why??? Tumorcell TumorcellTumorcell Tumorcell Clinical tumor Tumorcell Tumorcell Tumorcell

Rejection mechanisms Grafts Grafts rejection Immune System Immune response Recipient Ag

Overview of Immunology Organs and tissues Cells Molecules － Antibodies － Complement － Cytokines － MHC Components of IS Functions of IS Pathology of IR * IS: Immune system IR: Immune response Applications Prevention Diagnosis Therapy Antigen (Ag) Immune Responses Control mechanisms Hypersensitivity Autoimmune disease Immunodeficiency Tumor Transplantation rejection

Study of immunology** （一） 免疫学基本理论部分： 20 学时。 语言：以英文授课为主、中文总结为辅。 教材：采用国外英文教材为主、中文教材为辅。 授课方式 : 自讲与讲授两种相结合； 考试方式： 50 分（闭卷考试）。 笔试（或口试）中英文必答、中文必答和中英文选答相结合。 （二） 免疫学研究进展部分： 20 学时。 语言：以中文授课为主。 授课方式： “ 以研究专题为中心 ” 。 考试方式： 50 分（开卷考试）。撰写综述。

免疫学基本理论部分： 20 学时 Organs and tissues [1] Cells [2] Molecules － Antibodies [3] － Complement [4] － Cytokines [5] － MHC [6] Components of ISFunctions of IS * IS: Immune system IR: Immune response Antigen (Ag) [7] Immune Responses [8] Control mechanisms [9]