Applications   Heart Mitral Valves   Cardiovascular Biomechanics   Modeling Tissue Damage   Improved Surgical Repair Strategies Algorithms & Modeling   Image-Based Reconstruction   Patient Specific Models   Explicit Transient Dynamics   Strong Nonlinearities   Complex Geometry and Material Properties Funding: NIH, AHA CCS Research 3D model of the collagen fiber structure of the mitral heart valve showing regional levels of fiber alignment. Michael Sacks Director Affiliated Faculty Chandra Bajaj Kent Beasley George Biros Tom Hughes Laura Suggs Research Staff: Shaolie Hossain, Joao Soares, Ankush Aggarwal, Michael Hill, Chung- Hao Lee, Samarth Raut

2 Cardiovascular Research Cardiovascular Research - A 3D Anatomically Accurate Heart Mitral Valve - CCS The valve prevents backflow of blood from the left ventricle into the left atrium of the heart. Two leaflets that guard the valve opening, one anterior (red), and one posterior (green), that close when the left ventricle contracts. The yellow tendons connect the valve to the papillary muscle that prevents backflow. Computational Model: ~2M Elements ~500K DoFs

3 Cardiovascular Research Cardiovascular Research - Mitral Valve Simulation - CCS Dynamic simulation of the closure of a heart mitral valve due to transvalvular pressure. The computational model is used to investigate the mechanics, surgical repair-induced stresses, and resulting tissue damage. Such models enable the design of improved surgical repair strategies with enhanced long-term valve durability. Reduced Computational Model: Explicit Dynamics -- 40K DoFs Dt = 2.0x10 -7 sec M time steps Simulation Time: sec