Preparation and Characterization of Dexketoprofen Tromethamol Loaded Eudragit ® RS 100 Nanoparticles Ahmet Alper Öztürk, Evrim Yenilmez, Yasemin Yazan.

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Presentation transcript:

Preparation and Characterization of Dexketoprofen Tromethamol Loaded Eudragit ® RS 100 Nanoparticles Ahmet Alper Öztürk, Evrim Yenilmez, Yasemin Yazan Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Eskişehir, TURKEY

Flow NANOTECHNOLOGY, AUGUST 2015, FRANKFURT

AIM Dexketoprofen Tromethamol (DT) + Eudragit ® RS 100 (ER) Incorporation of DT into ER nanoparticles Characterization studies NANOTECHNOLOGY, AUGUST 2015, FRANKFURT

pH-sensitive non-biodegradable positively charged non-toxic Eudragit ® RS 100 (ER) NANOTECHNOLOGY, AUGUST 2015, FRANKFURT

non-steroidal anti-inflammatory drug dextrorotatory enantiomer of ketoprofen formulated as tromethamine salt medicine used in treatment of mild to moderate pain Dexketoprofen Tromethamol (DT) distribution half-life 0.35 hours elimination half-life 1.65 hours NANOTECHNOLOGY, AUGUST 2015, FRANKFURT

stable small size high surface area protect encapsulated drugs from GI environment modulate physicochemical characteristics, drug release and biological behavior Orally applied nanoparticles NANOTECHNOLOGY, AUGUST 2015, FRANKFURT

EXPERIMENTAL NANOTECHNOLOGY, AUGUST 2015, FRANKFURT

Eudragit ® RS 100 (ER)1 g Dexketoprofen Tromethamol (DT)0.05 g / 0.1 g / 0.15 g Methanol100 mL Preparation of ER-DT nanoparticles Buchi B-90 Nano Spray Dryer Inlet 120°C Outlet54°C NANOTECHNOLOGY, AUGUST 2015, FRANKFURT

Characterization NANOTECHNOLOGY, AUGUST 2015, FRANKFURT

DETERMINATION of DT by HPLC NANOTECHNOLOGY, AUGUST 2015, FRANKFURT

ResultS NANOTECHNOLOGY, AUGUST 2015, FRANKFURT

Composition of ER-DT Nanoparticles E RS-1 ER1 g DT0.05 g Methanol100 mL Placebo ER1 g DT - Methanol100 mL E RS-2 ER1 g DT0.1 g Methanol100 mL E RS-3 ER1 g DT0.15 g Methanol100 mL NANOTECHNOLOGY, AUGUST 2015, FRANKFURT

Morphology DT Placebo E RS-1 E RS-2 E RS-3 NANOTECHNOLOGY, AUGUST 2015, FRANKFURT

Particle Size, Zeta Potential (n=3, mean±SD) NANOTECHNOLOGY, AUGUST 2015, FRANKFURT

Particle Size, Zeta Potential (n=3, mean±SD) NANOTECHNOLOGY, AUGUST 2015, FRANKFURT

DSC ( Differantial Scanning Calorimeter) NANOTECHNOLOGY, AUGUST 2015, FRANKFURT

XRD Placebo E RS-1 E RS-2 E RS-3 NANOTECHNOLOGY, AUGUST 2015, FRANKFURT DT

FT-IR

H 1 NMR

Conclusion NANOTECHNOLOGY, AUGUST 2015, FRANKFURT

Thanks for your attention : )