اپیدمیولوژی و عوامل خطر اختلالات اورولوژی در سالمندان ارزیابی و تشخیص اختلالات اورولوژی در سالمندان

Urinary incontinence is a major problem for the elderly: It afflicts 15% to 30% of older people living at home, one third of those in acutecare settings, and half of those in nursing homes UI is twice as common in women as in men

Risk factors in women Pregnancy and vaginal delivery are significant risk factors, but become less important with age. Diabetes mellitus is a risk factor in most studies pelvic organ prolapse (POP)

Risk factors in men increasing age, lower urinary tract symptoms (LUTS), infections, functional and cognitive impairment, neurological disorders and prostatectomy.

perineal rashes, pressure ulcers, UTI, urosepsis, falls, and fractures embarrassment, stigmatization, isolation, depression, anxiety, sexual dysfunction,

cost more than $26 billion to manage incontinence in America’s elderly in 1995

THE IMPACT OF AGE ON INCONTINENCE However, it appears that although bladder capacity does not change with age, bladder sensation, contractility, and the ability to postpone voiding decline in both sexes, while urethral length and maximum closure pressure, as well as striated muscle cells in the rhabdosphincter and urogenital diaphragm, probably decline withage in women

Venous insufficiency, renal disease, heart failure, or BPH

طبقه بندی بی اختیاری ادرار بر اساس زمان استمرار مشکل : الف - بی اختیاری ادرار گذرا : چنانچه سالمند داراي حداقل يك نشانه به صورت غير دايمي و گاهي اوقات از روز است در طبقه « در معرض مشکل » بي اختياري ادرار گذرا قرار مي گيرد. ب - بی اختیاری ادراری دایمی : چنانچه سالمند داراي حداقل يك نشانه به صورت هميشگي يا اكثر اوقات در روز است، در طبقه « مشكل » بي اختياري ادراري دايمي قرار مي گيرد.

CAUSES OF TRANSIENT INCONTINENCE: “DIAPERS” Delirium/ confusional state Infection—Urinary Atrophic urethritis/ vaginitis Pharmaceuticals Excess urine output Restricted mobility Stool impaction

Commonly Used Medications That May Affect Continence Sedatives/hypnotics Alcohol Anticholinergics Narcotic analgesics(opiates) retention, fecal impaction α-Adrenergic antagonists & agonists: SUI in women

Calcium channel blockers: fluid retention Potent diuretics NSAIDs: Nocturnal diuresis due to fluid retention Parkinson agents (some) ACE inhibitors: cough can precipitate SUI in women and in some men with prior prostatectomy

جدول داروهاي به وجود آورنده يا تشديد كننده بي اختياري ادراري

Excess urine output excessive fluid intake; Diuretics metabolic abnormalities (e.g., hyperglycemia and hypercalcemia); fluid overload: CHF, peripheral venous insufficiency, hypoALB drug-induced peripheral edema: NSAIDs, Ca channel blockers amantadine (for Parkinson disease and influenza), and β blockers.

Restricted mobility arthritis, hip deformity, postural or postprandial hypotension, claudication, spinal stenosis, heart failure, poor eyesight, fear of falling, stroke, foot problems, drug induced disequilibrium or confusion, or being restrained in a bed or chair

stool impaction urge or overflow incontinence and typically have associated fecal incontinence as well.

History “urge” Urinary frequency (greater than seven diurnal voids) Nocturia: 3 general reasons: excessive urine output, sleep-related difficulties, and urinary tract dysfunction

 تکرر ادرار ( حداقل سه بار از صبح تا ظهر )  بيدار شدن مکرر از خواب براي ادرار كردن ( حداقل دو بار در کمتر از 10 ساعت )  باريك شدن يا قطع شدن و دوباره جريان يافتن ادرار ( معمولاً در مردان )  احساس ناگهاني و شديد براي ادرار كردن و ريزش ادرار قبل از رسيدن به دستشويي  خروج بي اختيار ادرار هنگام عطسه، سرفه، خنده و يا برخاستن ( معمولاً در زنان )  طول مدت بی اختیاری ادرار ( اکثر اوقات در روز یا همیشگی، گاهی اوقات در روز یا گذرا )  * علایم عفونت ادرار : تكرر ادرار، سوزش ادرار، ادرار تیره ( هماچوری ) واحساس باقی ماندن ادرار

Stress Urinary Incontinence Urge Urinary Incontinence / OAB Overflow Urinary Incontinence True Urinary Incontinence

توصيه هايي براي Stress Incontinence هر دو ساعت براي ادرار كردن به توالت برود. در طول روز 6 تا 8 ليوان مايعات بنوشد. بعد از ساعت 8 شب از نوشيدن مايعات خودداري كند. لباس هاي آزاد و راحت بپوشد. عضلات كف لگن را تقويت كند. مثانه را تقويت كند. اگر فرد چاق است، وزن خود را کاهش دهد. در حین سرفه و یا عطسه عضلات کف لگن را منقبض کند.

توصيه هايي براي Urge Incontinence براي داشتن آرامش تمرين كند. ( تمرينات آرام سازي بخش بيماري هاي قلبي و عروقي ) از ورزش هاي سخت اجتناب كند. قهوه، نوشابه هاي گازدار، غذاهاي پرادويه ميل نكند. از بروز یبوست پیشگیری کند.

توصيه هايي براي Overflow Incontinence در اين حالت سالمند، علائم انسدادی و احساس باقی ماندن ادرار دارد. شب ها معمولاً براي ادرار كردن از خواب بيدار مي شود، جریان ادرار ضعیف است يا حين ادرار كردن قطع و دوباره وصل مي شود و سالمند نیاز به زور زدن برای ادرار کردن دارد، اين حالت بيشتر در مردها ديده مي شود. در طول روز 6 تا 8 ليوان مايعات بنوشد. بعد از ساعت 8 شب از نوشيدن مايعات خودداري كند ( تقریبا سه ساعت قبل از خواب ). در زمان ادرار كردن عضلات شكم را سفت كند. سپس به آرامي با دست زير شكم را به سمت پايين فشار دهد. اين فشار به مثانه منتقل شده و به تخليه ادرار كمك مي كند.

ESTABLISHED INCONTINENCE Lower Urinary Tract Causes Detrusor overactivity (DO) is the most common type of lower urinary tract dysfunction in incontinent elderly of either sex

one in which contractile function is preserved and one in which it is impaired: The latter condition is termed detrusor hyperactivity with impaired contractility (DHIC) and is likely the most common form of DO in the elderly

SUI is the second most common cause of incontinence in older women. In men, SUI is usually due to sphincter damage following radical prostatectomy

Incontinence in the setting of outlet obstruction is the second most common cause of incontinence it generally presents as urge incontinence owing to the associated DO;

Detrusor underactivity is usually idiopathic When it causes incontinence, detrusor underactivity is associated with overflow incontinence

Causes Unrelated to the Lower Urinary Tract (“Functional” Incontinence) attributed to deficits of cognition and mobility. may still have obstruction or stress incontinence and benefit from targeted therapy

DIAGNOSTIC APPROACH Evaluation The evaluation should identify transient and established causes of incontinence, assess the patient’s environment and available support, and detect uncommon but serious conditions that may underlie incontinence

Voiding Diary 48 to 72 hours the diary records the time of each void and incontinent episode functional bladder capacity

Targeted Physical Examination neurologic diseases atrophic vaginitis general medical illnesses

Stress Testing and PVR Measurement The cough or strain PVR

Laboratory Investigation BUN, creatinine, U/A, U/C and PVR should be checked in all older patients. Serum sodium, calcium, and glucose should be measured in patients with confusion

The first step is to identify individuals with overflow inc (e.g., PVR > 450 mL) Because obstruction and underactive detrusor cannot be differentiated clinically The next step is to search for hydronephrosis in men whose PVR exceeds 200 mL and to decompress those in whom it is found

Urodynamic Testing When diagnostic uncertainty may affect therapy and when empiric therapy has failed and other approaches would be tried.

راه هاي تقويت عضلات كف لگن تمرين اول : هر بار كه براي ادرار كردن به توالت مي رود، چندين بار به طور ارادي، دفع ادرار را شروع و قطع كند. تمرين دوم : ناحية مقعد را سفت كند، مانند حالتي كه مي خواهد مانع دفع مدفوع شود و اين حالت را براي مدت 5 ثانيه حفظ نموده و بعد رها كند. در طول انقباض، نفس خود را حبس نكند. اين كار را چندين بار در طول روز انجام دهد. تكرار تمرين بايد در حدي باشد كه خسته نشود. اين تمرين را می تواند در حالت ايستاده، نشسته و يا خوابيده انجام دهد.

- در همه انواع بي اختياري ادرار، از ورزش هاي سخت اجتناب نموده و غذاهاي پر ادويه مصرف نکند. - بهتر است به جای مصرف مقدار زیاد مایع در یک نوبت، مقادیر کم مایعات، در نوبت های بیشتر و به فواصل کوتاه در طول روز مصرف شود. - در افرادی که ادم اندام تحتانی دارند، بالا نگه داشتن پاها در غروب باعث کاهش شب ادراری می شود. - اگر فرد دچار آلزایمر است، باید هر سه ساعت به او یادآوری کرد که به دستشویی برود.

Thank you Dr. Peyman Salehi

Stepwise Approach to Treatment of Urinary Incontinence

Detrusor overactivity with normal contractility (DO): Urge Bladder retraining or prompted voiding regimens pharmacologically and add intermittent or indwelling catheterization

Drugs used in the treatment of OAB/detrusor overactivity (DO) Antimuscarinic drugs: Tolterodine Drugs acting on membrane channels: Calcium antagonists Drugs with mixed actions: Oxybutynin, Dicyclomine, Flavoxate Antidepressants: Imipramin, Duloxetine Toxins: Botulinum toxin (neurogenic), injected into bladder wall

Detrusor hyperactivity with impaired contractility (DHIC): Urge If bladder empties adequately, behavioral methods If residual urine ≥150 mL, augmented voiding techniques or intermittent catheterization

Stress incontinence: Stress 1. Conservative methods (weight loss if obese; treatment of cough or atrophic vaginitis; physical maneuvers to prevent leakage [e.g., tighten pelvic muscles before cough, cross legs]; occasionally, use of tampon or pessary is useful)

2. If leakage threshold ≥150 mL identified, adjust fluid excretion and voiding intervals appropriately 3. Pelvic muscle exercises 4. Surgery (sling, artificial sphincter, periurethral bulking injections)

Urethral obstruction Urge/overflow 1. Conservative methods (including adjustment of fluid excretion, bladder retraining/ prompted voiding) if hydronephrosis, recurrent symptomatic UTI, and gross hematuria have been excluded 2. α-Adrenergic antagonist

3. Also consider adding a bladder relaxant if DO coexists, PVR is small, and surgery not desired/feasible; monitor PVR! 4. Finasteride, if the patient either prefers it or is not a surgical candidate 5. Surgery (incision, prostatectomy) is an effective alternative before or after these steps

Underactive detrusor Overflow 1. Decompress for at least several days (the larger the PVR, the longer should be the decompression [up to a month]) and then perform a voiding trial 2. Exclude urethral obstruction if this has not already been done 3. If cannot void or PVR remains large, try augmented voiding techniques 4. α-Adrenergic antagonist

For cognitively impaired patients, “prompted voiding” is used Asked every 2 hours whether they need to void, patients are escorted to the toilet if the response is affirmative

Thus oxybutynin and tolterodine should be considered first-line pharmacotherapy in this population Regardless of which antimuscarinic is used, urinary retention may develop. The PVR and urine output should be monitored, especially with DHIC, in which the detrusor is already weak.

Other remedies for urge incontinence, including electrical stimulation and selective nerve blocks, are successful in selected situations

there is little evidence that vasopressin is effective for geriatric incontinence the high prevalence of contraindications to its use (e.g., hyponatremia, renal insufficiency, heart failure), the risk of inducing serious hyponatremia with fluid retention, the potentially adverse impact on calcium and potassium excretion

Hormonal treatment of UI Oestrogen local administration may be the most beneficial route

Condom catheters helpful for men, but they are associated with skin breakdown, bacteriuria, and decreased motivation to become dry

Indwelling urethral catheters are not recommended for detrusor overactivity because they usually exacerbate it

Stress Incontinence weight loss Caffeine intake reduction, by postural maneuvers : Crossing the legs and bending forward during coughing By therapy of precipitating conditions such as atrophic vaginitis or cough (e.g., due to an ACE inhibitor), and by insertion of a pessary

Pelvic muscle exercises can decrease incontinence substantially in older women who are motivated

Older women generally can tolerate a suburethral sling but the ability to perform the midurethral procedures under regional, or even local, anesthesia on an outpatient basis makes them more feasible

Other treatments for sphincter incompetence include: periurethral bulking injections and insertion of an artificialsphincter

Periurethral collagen injection

Outlet Obstruction α-adrenergic antagonists: tamsulosin and alfuzosin, are more selective The 5α-reductase inhibitors (finasteride or dutasteride) have also proved effective as monotherapy

Underactive Detrusor The first step is to use indwelling or intermittent catheterization: (at least 7 to 14 days) For patients presenting with acute retention, an α blocker should be used as well.

Bethanechol (40 to 200 mg/day in divided doses) is occasionally useful in a patient whose bladder contracts poorly because of treatment with anticholinergic agents that cannot be discontinued (e.g., tricyclic antidepressant).

Principles of Indwelling Catheter Care upper thigh or abdomen Empty the bag every 8 hours. Do not routinely irrigate the catheter Surveillance cultures are unnecessary to change it every 1 to 2 months