FAMILY CALICIVIRIDAE. Viral Morphology Non-enveloped: 27-40 nm (+) ss RNA Some cultivable and some no Replication: cytoplasm.

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Presentation transcript:

FAMILY CALICIVIRIDAE

Viral Morphology Non-enveloped: nm (+) ss RNA Some cultivable and some no Replication: cytoplasm

Structure

Noroviruses Taxonomy Caliciviridae: Genus: 1.Norovirus : Norwalk virus (1968, Norwalk OH) 2.Sapovirus : Sapporo-Like Virus 3.Lagovirus : Rabbit Hemorrhagic Disease Virus 4.Vesivirus : Vesicular Exanthem Virus 1 & 2 : human and non cultivable 3 & 4 : animal and cultivable

Path of Infection Wagner et al. Basic Virology.

Norovirus : Norwalk virus Incubation period: hours gastroenteritis “winter vomiting disease” Mistakenly termed- “stomach flu” Highly contagious: fewer than 100 virus particles can cause infection

Epidemiology and Incidence The most important cause of Epidemic Viral gastroenteritis in Adult(40-50%) Found Worldwide. 267,000,000 annual cases 612,000 hospitalizations 3,000 deaths

Prevention and Control Vaccine not likely. No current antiviral drugs Prevent by : 1.hand-washing 2. good hygiene 3.preparation of food

Asteroviruses 28-30nm +Ss-RNA Mamastoviruses ( all human viruses) Diarrheal in infant, children, elderly person and immunocompromised persons. Transmission: fecal-oral, food,water and person to person