Adeno-Associated Virus-2-Mediated bFGF Gene Transfer to Digital Flexor Tendons Significantly Increases Healing Strength by Jin Bo Tang, Yi Cao, Bei Zhu,

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Presentation transcript:

Adeno-Associated Virus-2-Mediated bFGF Gene Transfer to Digital Flexor Tendons Significantly Increases Healing Strength by Jin Bo Tang, Yi Cao, Bei Zhu, Ke-Qin Xin, Xiao Tian Wang, and Paul Y. Liu J Bone Joint Surg Am Volume 90(5): May 1, 2008 ©2008 by The Journal of Bone and Joint Surgery, Inc.

Line drawings and photographs illustrating vector production and the delivery of AAV2-bFGF gene to the tendon. Jin Bo Tang et al. J Bone Joint Surg Am 2008;90: ©2008 by The Journal of Bone and Joint Surgery, Inc.

Diagram illustrating the assignment of chickens and their toes to different time-points of evaluation and experimental groups. Jin Bo Tang et al. J Bone Joint Surg Am 2008;90: ©2008 by The Journal of Bone and Joint Surgery, Inc.

Photographs and diagrams illustrating the test setup for determination of the work of simulated active digital flexion. Jin Bo Tang et al. J Bone Joint Surg Am 2008;90: ©2008 by The Journal of Bone and Joint Surgery, Inc.

Bar graphs illustrating the ultimate strength of the repaired flexor digitorum profundus tendon at two, four, and eight weeks after surgery. Jin Bo Tang et al. J Bone Joint Surg Am 2008;90: ©2008 by The Journal of Bone and Joint Surgery, Inc.

At four weeks, the flexor tendons that had been treated with AAV2-bFGFshowed a smoother gliding surface and better tissue continuity at the repair site than did the tendons without treatment. Jin Bo Tang et al. J Bone Joint Surg Am 2008;90: ©2008 by The Journal of Bone and Joint Surgery, Inc.

Line graph illustrating adhesions scores at four evaluation time-points. Jin Bo Tang et al. J Bone Joint Surg Am 2008;90: ©2008 by The Journal of Bone and Joint Surgery, Inc.

Bar graph illustrating the work of simulated active flexion of the digits at eight and twelve weeks after surgery. Jin Bo Tang et al. J Bone Joint Surg Am 2008;90: ©2008 by The Journal of Bone and Joint Surgery, Inc.