Atherosclerotic lesion area within the aortic sinus of apoE - / - and apoE - / - - hCRP + mice Gideon M. Hirschfield et al. PNAS 2005;102:8309– 8314.

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Atherosclerotic lesion area within the aortic sinus of apoE - / - and apoE - / - - hCRP + mice Gideon M. Hirschfield et al. PNAS 2005;102:8309– 8314

Typical atherosclerotic plaques in the aortic sinus of an apoE - / - - hCRP + mouse at 20 weeks Gideon M. Hirschfield et al. PNAS 2005;102:8309– 8314 (A) Oil red O stain. (B) Hematoxylineosin stain (C) Immunostain with anti- human CRP antibody. (D) Immunostain with anti- mouse C3 antibody. (E) Immunostain with anti- human CRP antibody preabsorbed with immobilized pure human CRP, showing complete absence of staining observed in C. (F) Anti-mouse C3 antibody preabsorbed with immobilized mouse C3, showing complete absence of staining observed in D

Serum concentrations of mouse SAP and human CRP in apoE - / - and apoE + / + mice with and without transgenic human CRP Gideon M. Hirschfield et al. PNAS 2005;102:8309– 8314

Serum concentrations of estradiol and testosterone at age 50 weeks in apoE - / - and apoE + / + mice with and without transgenic human CRP Gideon M. Hirschfield et al. PNAS 2005;102:8309– 8314