PDGF PDGFR Mitogenesis Actin Reorganization Figure 1. PI3K Raf-1 MEK c-fosc-jun MAP Kinase Erk Rac Rho Ras Grb2 mSos

mM NaCl Balb membranes plus fractionsBalb PDGF-BB B+K Figure 2. PDGF  R

Figure PDGF-BB mM NaCl  -Syp PDGF  R

Figure 4. AB CD

Table 1. Preatment of Balb and Kbalb cells with sodium vanadate prior to PDGF-BB stimulation: Correlation with PDGF-  R kinase activity and cell phenotype. Cell typeVO 4 PDGF-  R kinase activity Phenotype Balb KBalb Untransformed fibroblast Transformed fibroblast Fibroblast-like

Figure 5. P FAK V T  Ras Rac Rho PI3K Pak ROK Ras MAPK cascade