Comment on “ApoE-Directed Therapeutics Rapidly Clear β- Amyloid and Reverse Deficits in AD Mouse Models” by Ina Tesseur, Adrian C. Lo, Anouk Roberfroid,

Slides:

Advertisements

Similar presentations

Baseline Patient Characteristics Bart A.N. Verhoeven, et al. Stroke 2006;37:

Advertisements

Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model by Gerhard Leinenga, and Jürgen Götz Sci Transl Med Volume.

Glioma-derived soluble factor(s) enhance IL-10 signaling.

Early pathologic amyloid induces hypersynchrony of BOLD resting-state networks in transgenic mice and provides an early therapeutic window before amyloid.

Comment on “ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models” by Karthikeyan Veeraraghavalu, Can Zhang, Sean.

Immunohistochemical staining for fibrin in wounds from Plg+/+ and Plg−/− mice treated with galardin or vehicle 7 days after surgery. Immunohistochemical.

PERK activator decreases pathological tau species in vivo

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS by Yasushi Ito, Dimitry Ofengeim, Ayaz Najafov, Sudeshna Das, Shahram.

Fig. 1. Generation of ERY974. Generation of ERY974. (A) Schematic illustration of ERY974 structure and the introduced mutations. The two Fab arms share.

Fig. 6. AZD6738 induces DNA damage and apoptosis and exhibits antitumor efficacy in xenograft models of high-risk medulloblastoma and neuroblastoma. AZD6738.

by Simon F. De Meyer, Alexander S. Savchenko, Michael S

Fig. 4. Bexarotene promotes PPARδ activation of target genes in mouse brain and muscle. Bexarotene promotes PPARδ activation of target genes in mouse brain.

Fig. 7. Role of PDE5 up-regulation in lung cancer–associated PH.

In vivo prophylactic and therapeutic efficacy of C12G6 in mice

Fig. 6. Treatment with a DLK inhibitor is neuroprotective and reverses stress-induced gene expression changes. Treatment with a DLK inhibitor is neuroprotective.

Fig. 5. Prophylactic treatment with GS-5734 reduces SARS-CoV disease.

Fig. 5. Wisper is associated with TIA1-related protein and regulates lysyl hydroxylase 2 expression. Wisper is associated with TIA1-related protein and.

by Guntur Fibriansah, Kristie D. Ibarra, Thiam-Seng Ng, Scott A

Fig. 4. Prion infectivity of skin samples from sCJD patients.

Fig. 5. Antitumor efficacy of ERY974 in immunocompetent human CD3 transgenic mice. Antitumor efficacy of ERY974 in immunocompetent human CD3 transgenic.

Fig. 1. Paclitaxel delays tumor growth and promotes infiltration of TIE2hi/VEGFhi macrophages and TMEM assembly. Paclitaxel delays tumor growth and promotes.

Fig. 5. Pharmacological JAK2 inhibition in vivo abrogates tumor-initiating potential after chemotherapy. Pharmacological JAK2 inhibition in vivo abrogates.

Fig. 8. Therapeutic effects of the transplantation of hiPSC-EPO–producing cells on renal anemia in adenine-treated mice. Therapeutic effects of the transplantation.

by Soyon Hong, Victoria F. Beja-Glasser, Bianca M

Fig. 4. Antitumor efficacy of ERY974 against various cancer types.

Fig. 1. Aberrant JNK pathway activation in mouse models of ALS and in spinal cord tissue from patients with sporadic ALS. Aberrant JNK pathway activation.

Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Volume 120, Issue 5, Pages (March 2005)

Fig. 3 In situ vaccination with CpG and anti-OX40 is therapeutic in a spontaneous tumor model. In situ vaccination with CpG and anti-OX40 is therapeutic.

Comment on “ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models” by Ashleigh R. Price, Guilian Xu, Zoe B. Siemienski,

Fig. 7 BRD0705 impairs colony formation in AML cell lines and patient cells and shows in vivo efficacy in multiple AML mouse models. BRD0705 impairs colony.

Patched1 Regulates Hedgehog Signaling at the Primary Cilium

Fig. 4. Improved tumor response to docetaxel in TNBC and trastuzumab in HER2-amplified PDX models with the addition of S Improved tumor response.

Comment on “Cortical folding scales universally with surface area and thickness, not number of neurons” by Marc H. E. de Lussanet Science Volume 351(6275):

Fig. 8 SQLE inhibitor terbinafine suppresses NAFLD-HCC growth in vitro and in vivo. SQLE inhibitor terbinafine suppresses NAFLD-HCC growth in vitro and.

Comparison of therapeutic efficacies of C12G6 and other bnAbs in mice

Assessment of intracerebral micro‐hemorrhages in APP23‐transgenic mice, dosed orally with CNP520 at 30 mg/kg for 3 months Assessment of intracerebral micro‐hemorrhages.

Fig. 7. Treatment with DLK inhibitors reduces p-c-Jun and protects against neuronal and synaptic loss in vitro and in ALS mouse models. Treatment with.

Fig. 1. Bexarotene promotes PPARδ activation to ameliorate the neurotoxicity of mutant huntingtin. Bexarotene promotes PPARδ activation to ameliorate the.

Congratulations! Now Get to Work

Fig. 6 Anticancer effects in PyMT-MMTV syngeneic and MDA-MB-231 xenograft-bearing mice. Anticancer effects in PyMT-MMTV syngeneic and MDA-MB-231 xenograft-bearing.

Fig. 3. VEGFR-3 signaling increases infiltration of naïve T cells in a CCR7-dependent manner. VEGFR-3 signaling increases infiltration of naïve T cells.

CD facilitates RCT in vivo and promotes urinary cholesterol excretion

Bexarotene is neuroprotective in mouse and human HD neurons in vitro

Fig. 3 CSF1 is expressed in human melanoma.

Fig. 5 ALRN-6924 shows robust antileukemic activity in primary AML cells and in vivo. ALRN-6924 shows robust antileukemic activity in primary AML cells.

Treatment with AZD5363 reduces the proportion of proliferating vascular endothelial cells and following RT, the influx of CD11b+ bone marrow‐derived cells.

The MEK inhibitor CI‐1040 reverses thickening, fibrosis, and angiogenesis in the parietal peritoneum of Cav1−/− mice upon exposure to PD fluidWT or Cav1−/−

ILK knockdown decreases mTOR signaling in PKD kidneys.

Co-localization between Aβ and synaptic terminals and evaluation of the synapse volume by array tomography. Co-localization between Aβ and synaptic terminals.

Ab-dependent synaptic loss and neuritic dystrophies in adult APP/PSEN1 and APP/PSEN1/APOEnull mice. Ab-dependent synaptic loss and neuritic dystrophies.

Performance of chronic METH-treated rats in the gambling test under the double-reward condition. Performance of chronic METH-treated rats in the gambling.

Quantification of TBS-, FA-soluble Aβ40/42, and Aβ oligomers in the brain of adult and aged APP/PSEN1 and APP/PSEN1/APOEnull mice. Quantification of TBS-,

Streptozotocin treatment increased phospho–Thr231-tau immunoreactivity in mouse brain. Streptozotocin treatment increased phospho–Thr231-tau immunoreactivity.

Fig. 2. Sufficient rate of recombination in embryonic NSCs and NPCs of Emx1cre knock-in mice.(A) Breeding schemes to generate mice with the Emx1cre locus.

Volume 120, Issue 5, Pages (March 2005)

Chronic rapamycin treatment impairs β-cell mass and insulin clearance in rats. Chronic rapamycin treatment impairs β-cell mass and insulin clearance in.

Fig. 4 Administration of BMS to mice inhibits autoimmune-relevant pharmacodynamic endpoints driven by IL-12 and IFNα. Administration of BMS

Fig. 5 Treatment with BMS (PO BID) protects from wasting and colitis in two SCID mouse models. Treatment with BMS (PO BID) protects from.

by Jinqiang Wang, Jicheng Yu, Yuqi Zhang, Xudong Zhang, Anna R

PVHA increased anti-PD-L1–mediated growth inhibition in 4T1/HAS3 tumors. PVHA increased anti-PD-L1–mediated growth inhibition in 4T1/HAS3 tumors. A, 4T1/HAS3.

Fig. 6. Microglial phagocytosis and lysosomal uptake of Aβ induced by SUS treatment. Microglial phagocytosis and lysosomal uptake of Aβ induced by SUS.

Pioglitazone induces the clearance of amyloid in APP/PS1 mice.

PDL192 and inhibit the growth of xenograft tumors.

Treatment with a Ron inhibitor significantly reduces metastatic outgrowth. Treatment with a Ron inhibitor significantly reduces metastatic outgrowth. A,

Fig. 4 In vivo evaluation of insulin complex for type 1 diabetic mice treatment. In vivo evaluation of insulin complex for type 1 diabetic mice treatment.

AV3 potentiates the effect of gemcitabine in the PDX model in mice

Recruitment of CD8+, CD4+, and Foxp3+ cells into oral lesions in response to anti–PD-1 treatment. Recruitment of CD8+, CD4+, and Foxp3+ cells into oral.

PEGPH20 depletes HA and decompresses intratumoral vessels.

Fig. 2. SUS reduces Aβ plaques in an AD mouse model.

Presentation transcript:

Comment on “ApoE-Directed Therapeutics Rapidly Clear β- Amyloid and Reverse Deficits in AD Mouse Models” by Ina Tesseur, Adrian C. Lo, Anouk Roberfroid, Sofie Dietvorst, Bianca Van Broeck, Marianne Borgers, Harrie Gijsen, Diederik Moechars, Marc Mercken, John Kemp, Rudi D’Hooge, and Bart De Strooper Science Volume 340(6135): May 24, 2013 Published by AAAS

Fig. 1 Soluble brain and CSF Aβ levels are not significantly reduced by bexarotene in wild-type CD1 mice and beagle dogs.(A) Soluble Aβx-37, Aβx-38, Aβx-40, and Aβx-42 levels (enzyme-linked immunosorbent assay) in whole-brain homogenate of wild-type CD1 mice treated with one dose of oral bexarotene (100 mg/kg; 20% Captisol; N = 6 mice) for 7, 24, 49, and 72 hours, and vehicle (N = 6 mice). Ina Tesseur et al. Science 2013;340:924 Published by AAAS

Fig. 2 Aβ levels and deposition are not reduced by chronic bexarotene treatment of hAPP/PS1 mice.(A) Representative pictures of cortical sections of control (vehicle) and bexarotene-treated (100 mg/kg per day; 20% Captisol) 10-month-old hAPP/PS1 transgenic mice (N = 9 per group) stained with horseradish peroxidase (HRP)–labeled antibody 6E10 to Aβ and tyramide- fluorescein (green) and 4′,6-diamidino-2-phenylindole (DAPI) (blue). Ina Tesseur et al. Science 2013;340:924 Published by AAAS