Contributions to Type 2 Diabetes. Glucose in balance meal Time in minutes Blood glucose levels, mg/dL -60 0 60 120 180 240 80 Insulin levels, uU/mL Glucagon.

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Presentation transcript:

Contributions to Type 2 Diabetes

Glucose in balance meal Time in minutes Blood glucose levels, mg/dL Insulin levels, uU/mL Glucagon pg/mL Unger, FH. N Engl J Med. 1971; 285:

Healthy (n=240) Prediabetes (n=191) Diabetes (n=100) Time (min) Blood Glucose levels (mg/dl) Blood Insulin levels (µU/ml) Jensen CC et al: Diabetes 51: ; 2002 Oral Glucose Tolerance Test Glucose given Fasting

Glucose in balance

Glucose in balance FPG – Fasting Plasma Glucose N – Number of people in that group

Glucose in balance

Diabetes incidence in three populations Schulz L O et al. Dia Care 2006;29:

Diabetes Prevention Program Data Lowest Genetic Highest Genetic Risk Risk Placebo Metformin Lifestyle changes Genetic risk group Diabetes incidence rate Cases/100 persons-years Copyright © 2011 American Diabetes Association, Inc. Jablonski K A et al. Diabetes 2010;59:

Copyright © 2011 American Diabetes Association, Inc. Diabetes Prevention Program Data Allele combinations: