-0.8 -0.6 -0.4 -0.2 0 0.2 0.4 05101520253035 -0.8 -0.6 -0.4 -0.2 0 0.2 0.4 0123456789 Supplementary Fig. 1 APACHE II score ( transformed) SOFA score (transformed)

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Supplementary Fig. 1 APACHE II score ( transformed) SOFA score (transformed) FT3(pmol/L)/FT4(pmol/L) ratio (transformed) (3.00) FT3(pmol/L)/FT4(pmol/L) ratio (transformed) (3.00) 0.493

MMI(mg) PTU(mg) FT3(pmol/L) PTU(mg) FT3(pmol/L) FT4(pmol/L) Supplementary Fig. 2

HC equivalent dose (mg) of CS (transformed) APACHE II score (transformed) SOFA score (transformed) (20) (5000) Supplementary Fig. 3 (5000) (20)