Cover illustration: Evolution of transcriptional regulatory networks in prokaryotes. See the article by Madan Babu et al. in this issue.

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Cover illustration: Evolution of transcriptional regulatory networks in prokaryotes. See the article by Madan Babu et al. in this issue.

Escherichia coli Bordetella pertussis Haemophilus influenzae Staphylococcus aureus Mycobacterium tuberculosis Cover illustration: Evolution of transcriptional regulatory networks in prokaryotes. See the article by Madan Babu et al. in this issue.

Escherichia coli Bordetella pertussis Haemophilus influenzae Staphylococcus aureus Mycobacterium tuberculosis Crp NarL Lrp Fnr Ihf PhoB FruR PurR Fur Cover illustration: Evolution of transcriptional regulatory networks in prokaryotes. See the article by Madan Babu et al. in this issue.

Escherichia coli Cover illustration: Evolution of transcriptional regulatory networks in prokaryotes. See the article by Madan Babu et al. in this issue. Bacillus anthracisStreptomyces coelicolor

Escherichia coli Cover illustration: Evolution of transcriptional regulatory networks in prokaryotes. See the article by Madan Babu et al. in this issue.

Transcription Factor Target gene Cover illustration: Evolution of transcriptional regulatory networks at multiple levels of organization. See the article by Madan Babu et al. in this issue.

Cover illustration: Matrix representation of the conservation of transcriptional regulatory interactions across 175 prokaryotes. See the article by Madan Babu et al. in this issue. Transcription Factor Target gene