Metabolism in Skeletal Muscle Eric Niederhoffer SIU-SOM Glycolysis Glycogenolysis  -oxidation (ketone bodies) Krebs (tricarboxylic acid) cycle Branched-chain.

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Presentation transcript:

Metabolism in Skeletal Muscle Eric Niederhoffer SIU-SOM Glycolysis Glycogenolysis  -oxidation (ketone bodies) Krebs (tricarboxylic acid) cycle Branched-chain amino acids Electron transport chain Calcium regulation Key enzyme regulation

Pathways Overview Acetyl-CoA Lactate No O 2 Production of ATP G6P Glucose Glycolysis Pyruvate BCAA Ile, Leu, Val Krebs cycle Electron Transport Chain Glycogen Glycogenolysis Ca 2+ PKa Ca 2+ PDH Ca 2+ ISDH,  KGDH Fatty acids  - Oxidation Ketone bodies

Regulation in Skeletal Muscle Fatty acids  - Oxidation Glc Glycolysis Glycogen Glycogenolysis PDH PK PFK-1 PKA AC cAMPATP Ep  AR Acetyl-CoAPyr F6P F16BP PEP Pi IMP AMP NH 4 + AMP Pi Ca 2+ PKa G6P PP Ca 2+ PDHP PDHK PDH P PDH PFK-2 F26BP ATP Citrate

Review Questions How does muscle produce ATP (carbohydrates, fatty acids, ketone bodies, branched-chain amino acids)? How is skeletal muscle phosphofructokinase-1 regulated? What are the key Ca 2+ regulated steps?