Ensemble Synchronization in Schizophrenia Kaushik Majumdar, ISI Bangalore Joint work with Pradeep D. Prasad (ISI), John P John (NIMHANS), H. N. Harsha.

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Presentation transcript:

Ensemble Synchronization in Schizophrenia Kaushik Majumdar, ISI Bangalore Joint work with Pradeep D. Prasad (ISI), John P John (NIMHANS), H. N. Harsha (Nitte University) (Computational Neuroscience Group) Electrical Geodesics Inc & Neuroinformatics Center, UO, 15 Nov. 2013

Video Synchronization: Snapshot

Pairwise Hilbert Phase Synchronization Prasad et al. Clin. EEG Neurosci. 44(1): 16 – 24, 2013

Hilbert Transformation and Instantaneous Phase

Phase Synchronization Prasad et al. 2012

Cross Modal Task

Videos  Healthy control subject  Patient with schizophrenia

Multi-channel synchronization

Single Trial Ensemble Synchronization

Trial Averaged Ensemble Synchronization

ERSP & ITC

Trial Selection

Classification by Logistic Regression  3 dimensional feature space: 1.Ensemble right hemispheric synchronization. 2.Ensemble left hemispheric synchronization. 3.Response latency.

2 Dimensional Projection of 3 Dimensional Feature Space Cross is patient with schizophrenia square is healthy control subject Incongruent stimulus

2 Dimensional Projection of 3 Dimensional Feature Space Congruent stimulus Plus is patient with schizophrenia circle is healthy control subject

2 Dimensional Projection of 3 Dimensional Feature Space Neutral stimulus Star is patient with schizophrenia diamond is healthy control subject

Average Accuracy

Probabilistic Score

Reference  P. D. Prasad, H. N. Halahalli, J. P. John and K. Majumdar, “Single-trial EEG classification using logistic regression based on ensemble synchronization,” accepted in IEEE Journal on Biomedical and Health Informatics.