Growth factor PI3K PDK1/2 PIP 3 AKT CASP9 FOXO1 BAD CDKN1A CDKN1B MDM2 GSK3B CHUK mTOR PTEN miR-26ab/1297; miR-148/152; miR-103/107; miR-19; miR-425/489;

Slides:

Advertisements

Similar presentations

Supplemental Figure 1 A No. at risk T T T

Advertisements

P449. p450 Figure 15-1 p451 Figure 15-2 p453 Figure 15-2a p453.

Supplimental figure 1. Melanoma free survival curve (A) and summary table (B) for median survival and melanoma free survival for each genotype. All of.

Targeting the IGF Pathway in Pediatric Sarcomas-Lessons Learned and Questions Raised Lee J. Helman, M.D. Scientific Director for Clinical Research,Center.

Not division…But growth. Cells must grow PI3K GFR Akt Rheb Ras mTOR Tuberin/ Hamartin PTEN Neurofibromin Tuberous sclerosis complex Neurofibromatosis.

MiR-19b/20a/92a regulates the self- renewal and proliferation of gastric cancer stem cells Journal of Cell Science (IF=5.325) 报告人：黄美玲

MicroRNA implication in urinary bladder cancer A. Zaravinos 1, J. Radojicic 3, G.I. Lambrou 2, D. Volanis 1,4, D. Delakas 4, E.N. Stathopoulos 3, D.A.

Supplemental Data Fig. 1A. Standard curves of miR-34c-5p using synthetic miRNAs.

Supplemental Fig. 1A. Standard curve of miR-30a-5p using synthetic miRNA.

Apostolos Zaravinos and Constantinos C Deltas Molecular Medicine Research Center and Laboratory of Molecular and Medical Genetics, Department of Biological.

OncomiR and tumor-suppressor miR expression in triple-negative primary breast cancer. Jelena Radojicic 1, Apostolos Zaravinos 2, Thomas Vrekoussis 1, Maria.

MiR-21 can be used as independent prognostic factor for survival and metastasis in urinary bladder cancer. Apostolos Zaravinos 1, Jelena Radojicic 3, George.

Affymetrix 2.0 miRNA arrays on lung tissue RNA n=3-4 mice/strain 92 differentially expressed miRNAs 38 miRNAs both differentially and highly expressed.

How to present a scientific paper Dr. Rebecca B. Riggins Department of Oncology, Georgetown University

Partial recovery Lost sample 1,000 fmols 0.1 fmols 1.0 fmols Neg. control Supplemental Fig. 1. Quality control for extraction procedures using spiked-in.

Supplemental Table 1. Oligonucleotide sequences used for mRNA expression analysis by qPCR. Primer name Forward Primer 5’- 3’Reverse Primer 5’-3’ KLK3 5’-GTGCTTGTGGCCTCTCG-3’

MicroRNAs as Biomarkers for Acute Graft Versus Host Disease Prediction

Expression profile of oncomiRs and tumor-suppressor miRs in urothelial carcinoma of the bladder Apostolos Zaravinos 1, George I. Lambrou 2, Jelena Radojicic.

Figure S1 cmSP165/166 severe b MIM159 (mir159a) a Figure S1: Detailed phenotype of severe cmSP165/166 and MIM159 plants. Severe cmSP165/166 (15x) plants.

Yuna Jo. Introduction Prostate cancer (PCa) continues to burden the Western world with its high rates of incidence and mortality despite the.

Author(reference) down up Supplemental data S1. differentially expressed miRNAs in selected microarray studies Murakami (14)miR-18, miR-224miR-199a, miR-195,

ANIMAL TARGET PREDICTION - TIPS

Oncogene activation Transcription DNA damage MDM2 CDKN2A MDM4 p53 ATR

Additional file 5 Novel and conserved miRNAs in the halophyte Suaeda maritima identified by deep sequencing and computational predictions using the ESTs.

Pathways regulating autophagy

Figure 1 miRNA expression in multiple sclerosis lesions

Skin Pharmacol Physiol 2017;30: DOI: /

Supplemental Figure and Tables Legends

Sustaining Proliferative Signaling and Evading Growth Suppressors

Leptin and insulin signalling pathways in the Arc.

GRB2 SOS1/2 SHC 1/2/3/4 PDGFR PDGF EGFR EGF PKC SPHK 1/2 RAS RAF1

Florie Borel, Pavlina Konstantinova, Peter L.M. Jansen

Figure 3 Defects in the T cell receptor signalling pathway

John S. Tsang, Margaret S. Ebert, Alexander van Oudenaarden

Taking T Cell Priming Down a Notch: Signaling through Notch Receptors Enhances T Cell Sensitivity to Antigen Timothy J. Thauland, Manish J. Butte Immunity

A Flt3L Encounter: mTOR Signaling in Dendritic Cells

Regulating Cancer Stem Cells the miR Way

The Increasing Diversity of KRAS Signaling in Pancreatic Cancer

In-vitro regulation of primordial follicle activation: challenges for fertility preservation strategies Michael J. Bertoldo, Kirsty A. Walters, William.

The pathway signalling starts with the binding of insulin or growth factors to insulin receptors. The pathway signalling starts with the binding of insulin.

RIDD of miRNA (miRIDD) signals in GBM

MiR‐199a directly targets ERBB2 and ERBB3, whereas miR‐125b targets ERBB3. miR‐199a directly targets ERBB2 and ERBB3, whereas miR‐125b targets ERBB3. (A)

A Pilot Characterization of Human Lung NSCLC by Protein Pathway Activation Mapping Angela Zupa, BS, Giuseppina Improta, BS, Alessandra Silvestri, PhD,

Structure-function models of novel mutants in the PI3K-PTEN-AKT pathway. Structure-function models of novel mutants in the PI3K-PTEN-AKT pathway. A, schematic.

How to present a scientific paper

Andrew D. Bosson, Jesse R. Zamudio, Phillip A. Sharp Molecular Cell

Nat. Rev. Nephrol. doi: /nrneph

John S. Tsang, Margaret S. Ebert, Alexander van Oudenaarden

AKT/PKB Signaling: Navigating the Network

Plasma Cells for Hire: Prior Experience Required

Promotion Effects of miR-375 on the Osteogenic Differentiation of Human Adipose- Derived Mesenchymal Stem Cells Si Chen, Yunfei Zheng, Shan Zhang, Lingfei.

Youry Kim, Jenny L. Anderson, Sharon R. Lewin Cell Host & Microbe

AKT/PKB Signaling: Navigating Downstream

Figure Overview.

Pathway analysis of genes upregulated after RSV infection.

Figure Overview.

Hilde van Hattum, Herbert Waldmann Chemistry & Biology

John D. Gordan, Craig B. Thompson, M. Celeste Simon Cancer Cell

mTOR and Akt Signaling in Cancer: SGK Cycles In

* PXN VEGFA/B/C VEGFR2 SHC2 SRC CDC42 PLCG 1/2 SH2D2A PI3K MAPK14

Genes frequently mutated in colorectal cancer and their relationships with miRNAs. Genes frequently mutated in colorectal cancer and their relationships.

Alex Kentsis, A. Thomas Look Cell Stem Cell

Proposed model of how USP2a-driven microRNA deregulation enhances MYC protein expression through impairment of the MDM2–p53 pathway. p53 regulates miR-34b/c.

Volume 20, Issue 1, Pages 1-12 (July 2017)

Supplemental figures.

The critical roles of miR-23a and miR-27a in colorectal cancer progression. miR-23a primarily increases cell motility through downregulation of its target.

Successful targeting of ErbB2 receptors—is PTEN the key?

Turning Reciprocal Feedback Regulation into Combination Therapy

Skp2, the FoxO1 hunter Cancer Cell

Presentation transcript:

Growth factor PI3K PDK1/2 PIP 3 AKT CASP9 FOXO1 BAD CDKN1A CDKN1B MDM2 GSK3B CHUK mTOR PTEN miR-26ab/1297; miR-148/152; miR-103/107; miR-19; miR-425/489; miR-29abc; miR-130/301; miR- 25/32/92/92ab/363/367; miR-23ab; miR-141/200a; miR- 338/338-3p; miR-132/212; miR-22; miR-144; miR-17- 5p/20/93.mr/106/519.d; miR-205; miR-139-5p; miR-181; miR-200bc/429; miR-365; miR-216/216a; miR-214/761; miR-10; miR-153; miR-193ab; miR-183; miR-106/302; miR-194; miR-490/490-3p; miR-217; miR-129/129-5p miR-21 miR-203; miR-106/302; miR-10; miR-148/152; miR- 155; miR-19; miR-124/506; miR-132/212; miR- 124/506; miR-122; miR-203; miR-143; miR-142-3p; miR-25/32/92/92ab/363/367; miR-33/33ab; miR- 129/129-5p; miR-24 miR-130/301; miR-96/1271; miR-128; miR-138; miR-216/216a; miR p; miR-148/152; miR-155; miR-143; miR-27ab; miR-137; miR- 181; miR-150; miR-425/489; miR-7/7ab; miR-129/129-5p; miR-22; miR-140/140-5p/876-3p; miR-187; miR-216/216b; miR-9; miR-182; miR-125/351; miR-205; miR-375; miR-25/32/92/92ab/363/367; miR- 33/33ab; miR-19; miR-133; miR-23ab; miR-24 miR-214/761; miR-490/490-3p; miR- 218; miR-125/351; miR-24; miR-31; miR-128; miR-124/506; miR-141/200a miR-106/302; miR-138; miR- 183; miR-338/338-3p; miR- 143; miR-22 miR-144; miR-96/1271; miR-7/7ab; miR-99ab/100; miR-135; miR-101; miR-375; miR-128; miR-103/107 miR-26ab/1297; miR-199/199-5p miR-221/222; miR-26ab/1297; miR- 208/208ab; miR-499/499-5p; miR-10; miR- 194; miR-24 miR-23ab; miR-148/152; miR-15/16/195/424/497; let-7/98; miR-208/208ab; miR-499/499-5p; miR- 223; miR-21/590-5p; miR-133; miR-130/301; miR-425/489 miR-221/222; miR-150; miR-24; miR- 200bc/429; miR-196ab; miR-190; miR-218; miR-199/199-5p; miR-148/152; miR-181; miR- 194; miR-155; miR-34a/34b-5p/34c/34c- 5p/449/449abc/699; miR-141/200a; miR-153; miR-455/455-5p; miR-122; miR-223; miR- 129/129-5p miR-17-5p/20/93.mr/106/519.d; miR-365; let- 7/98; miR-130/301; miR-208/208ab; miR- 499/499-5p; miR-132/212; miR-22; miR-101; miR-124/506; miR-148/152; miR-199/199- 5p; miR-15/16/195/424/497; miR-141/200a; miR-145 miR-106 miR-223; miR-96/1271; miR-135; miR-101; miR- 128; miR-27ab; miR-21/590-5p; miR-183; miR- 132/212; miR-26ab/1297; miR-145; miR- 216/216a; miR-15/16/195/424/497; miR-196ab; miR-129/129-5p; miR-144; miR-143; miR-182; miR-200bc/429; miR-338/338-3p; miR-142-3p; miR-204/211; miR-194; miR-139-5p; miR- 490/490-3p; miR-9; miR-216/216b; miR-221/222; miR-153; miR-133; miR-218; miR-365 miR-153; miR-129/129-5p; miR-490/490-3p; miR-34a/34b-5p/34c/34c-5p/449/449abc/699 miR-182; miR-96/1271; miR-155; miR-146; miR- 130/301; miR-193ab; miR-7/7ab; miR-10; miR- 140/140-5p/876-3p; miR-124/506; miR-223 NOS3 miR-31; miR-155; miR-124/506; miR- 34a/34b-5p/34c/34c-5p/449/449abc/699 PDE3A: miR-128; miR-139-5p; miR-138; miR- 216/216b; miR-27ab; miR-21/590-5p; miR-155; miR-204/211; miR-218; miR-210 PDE3B: miR-205; miR-33/33ab; miR- 15/16/195/424/497; miR-103/107; miR-17- 5p/20/93.mr/106/519.d; miR-27ab; miR-181; miR- 9; miR-144; miR-153; miR-214/761; miR-223; miR-425/489; miR-499/499-5p; miR- 25/32/92/92ab/363/367; miR-141/200a; miR-128 PDE3 A/B GFR (e.g. ERBB2) Supplemental Figure 1. Overview of Akt signaling. Summary of Akt signaling and predicted miRNA interactions. miRNAs that were described to be downregulated in prostate cancer are highlighted in green, while upregulated miRNAs are highlighted in red; all other potential interactions are highlighted in black. Target interactions were predicted with TargetScan 5.1. miRNAs presented in this figure are all highly conserved among vertebrates; for a list of other miRNAs see Supplemental Table 1.