A B E F G C D NP460 vs HK1 (p<0.05) NP460 vs C666 (p<0.05) NP460 vs X666 (p<0.05) Index B C DE Significant in NPC Significant in HK1 only Significant in.

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A B E F G C D NP460 vs HK1 (p<0.05) NP460 vs C666 (p<0.05) NP460 vs X666 (p<0.05) Index B C DE Significant in NPC Significant in HK1 only Significant in C666 and X666 + A + NP460 vs HK1 (p<0.05) NP460 vs C666 (p<0.05) NP460 vs X666 (p<0.05) Protein-coding mRNA NP460 vs HK1 (p<0.05) Micro-RNA NP460 vs C666 (p<0.05) NP460 vs X666 (p<0.05) G + A

Log 2 X666/460 Log 2 HK1/460 Log 2 C666/460 Pathway enriched in Beta1 integrin cell surface interactions Pathway enriched in Extracellular matrix organization Pathway enriched in Cell adhesion Biological networks commonly enriched in HK1 and C666 B

Log 2 X666/460 Log 2 HK1/460 Log 2 C666/460 Pathway enriched in EGFR and PI3K/AKT signaling Micro-RNA regulated biological networks commonly enriched in HK1 and C666 C

Micro-RNA regulated biological networks commonly enriched in HK1 only Log 2 HK1/460 D

Log 2 C666/460 Log 2 X666/460 Micro-RNA regulated biological networks commonly enriched in C666/X666 Pathway enriched in cytokine signaling E

Log 2 C666/460 Log 2 X666/460 Pathway enriched in interferon signaling Micro-RNA regulated biological networks commonly enriched in C666/X666F