A Case Study Of A Man With Leukemia. A Chromosomal Translocation is Discovered.

Slides:

Advertisements

Similar presentations

neoplasia III tumour genetics MOLECULAR BASIS OF CANCER

Advertisements

E2A and acute lymphoblastic leukemias (ALL). A closer look at the E2A gene... Other names: TCF3, ITF1, and Factors E12/E47 Located on chromosome 19 Encodes.

Notch1 Transmembrane Receptor Oncogene. What is Notch1?  Transmembrane protein involved in a conserved and simple signaling pathway.

Notch1 and pre-T-cell Acute Lymphoblastic Leukemia (T-ALL) by Lindsey Wilfley.

Lecture 23 Signal Transduction 2

Notch1 and its role in pre T-cell Acute Lymphoblastic Leukemia (ALL) By Rebecca Goodman.

PDGF β Receptor. Protein 1106 amino acid protein Weinberg Fig 5.10.

Retinoic Acid Receptor Alpha (RARα) Acute Promyelocytic Leukemia (APL)

Retinoic Acid Receptor Alpha and Acute Promyelocytic Leukemia Nidhi Thapar April 1, 2004.

Anticancer Therapy: Kinase Inhibitors Charles Harrell.

1. Cancer and the cell cycle

Diseases of aging A&S Jim Lund There is still no cure for the common birthday. -John Glenn Assigned reading: Chapter 8, Handbook of Aging 5th ed.

A B. Breast Case-Control Analysis CaseControl PC X-sq=10.7, df=1, p=0.001 OR=2.9 ( ), p= A B C D EF GO Terms - Survival.

Gene Transcription G0G0 G1G1 Priming S G2G2 M Cell Cell Cycle Growth Factors + Growth Factors & Cell Cycle Receptors.

Acute Leukemia and the FLT3 Receptor B y: Betty Sa’ Mentor: Dr. Govind Bhagat Site: Columbia University Vanderbilt Clinic.

Here are some CML slides that may be helpful for your presentation.

The Function of VHL and pVHL Protein VHL is a tumor suppressor gene on chromosome 3 Helps to regulate and destroy the alpha subunit of hypoxia-inducible.

PDGF receptor β and leukemia Caleb Parker. Overview  What is PDGFRB?  What role does PDGFRB play in the cell?  What is CMML?  What is Tel/PDGFRB?

BIOL 445 – CANCER BIOLOGY PRESENTATION

Genetics of Cancer Lecture 34.

“Because clinical experience is still so limited, it is not possible to exclude longterm adverse effects of gene transfer therapy, such as might arise.

Vasculogenesis and angiogenesis Integrins in vasculature and KO phenotypes Growth Factor Receptors signaling and vasculature phenotypes VEGFR Tip cells.

Fibroblast growth factor receptor (FGFR) gene family aberrations in cholangiocarcinoma Katsuyuki Miyabe, MD, PhD Lewis R. Roberts, MB ChB, PhD.

The Role of Alk in Anaplastic Large-cell Lymphoma (ALCL) Andreas Staebler.

Dihydrofolate Reductase (DHFR)

Heterogeneous group of hematopoietic neoplasms Uncontrolled proliferation and decreased apoptotic activity with variable degrees of differentiation Composed.

Tyrosine Kinases as Targets for Cancer Therapy Krause DS, Van Etten RA N Engl J Med 2005;353(2): Krause DS, Van Etten RA N Engl J Med 2005;353(2):

What we will review this lecture: Receptor Tyrosine Kinase signalling: PI3K Pathway – AKT, PDK1, PTEN RTK Signalling in Cancer Historical description of.

Oncogenes Lecture 43BSCI 420,421,620Dec 13, 2002 “It ain’t over till the fat lady sings” – Joe Gibbs 1.Cancer-critical genes a. Oncogenes b. Tumor-suppressor.

Malignant diseases of the bone marrow Tornóci László Semmelweis University Institute of Pathophysiology.

Biology of Cancer Weeks 1 Introduction and 2 RTKs Dr. Michael Chorney Susquehanna Medicine and Health Science Magnet February 17 th -28 th, 2014.

T Cells Lacey Jeong. What is a T Cell?? Thymus cell – produced and processed by the thymus gland Lymphocyte (white blood cell) – protect body from infection.

Retinoic Acid Receptor α Acute Promyelocytic Leukemia Michi Nair.

LEUKEMIA Dr. Omar Alshaer. Acute Leukemia.

c-Myc A Biological Paradox

Figure 1. Microscopic findings and karyotyping

Table 1. The French-American-British (FAB) classification of AML

Higher Human Biology Unit 1 – Human Cells

Molecular consequences of chromosomal rearrangements that modify the AML1/CBFβ transcription factor complex, the most frequent target of reciprocal translocations.

Sekeres MA et al. Proc ASH 2015;Abstract 908.

Volume 76, Issue 9, Pages (November 2009)

The JAK-STAT signal-transduction pathway

Leukemia Human Disease Asma Siddique BIOT 412.

ETV6-NTRK3—Trk-ing the primary event in human secretory breast cancer

Fibroblast Growth Factor 3 (FGF3) int-2

The Role of Myc A Master Regulator Gone Awry

RNA Identity Crisis: Hepatitis B Walks the LINE

Chapter 17: Regulation of cell number

Is NF-κB2/p100 a direct activator of programmed cell death?

Ayalew Tefferi, M.D. Mayo Clinic Proceedings

Extracellular Regulation of Apoptosis

ETV6-NTRK3—Trk-ing the primary event in human secretory breast cancer

Lymphoid Preponderance and the Absence of Basophilia

(T-cell Acute Lymphoblastic Leukemia)

Cytokine-Release Syndrome in Patients With B-Cell Chronic Lymphocytic Leukemia and High Lymphocyte Counts After Treatment With an Anti-CD20 Monoclonal.

Systematic Literature Review of Treatment Options and Clinical Outcomes for Patients With Higher-Risk Myelodysplastic Syndromes and Chronic Myelomonocytic.

Volume 76, Issue 9, Pages (November 2009)

Targeting STAT3 in hepatocellular carcinoma: Sorafenib again…

Imatinib in Dermatofibrosarcoma: Targeted Therapy or Immunotherapy?

Challenges in Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN)

Illustration of Beta 11.

MYC on the Path to Cancer

Kantarjian HM et al. Blood 2008;112:Abstract 635.

Erythrocyte What type of cell is this?.

The Pathway to Progress Against Chronic Myelogenous Leukemia.

Supplementary Figure S5

TYK2 signaling in T-ALL. TYK2 signaling in T-ALL. TYK2 activates STAT1 through phosphorylation downstream of the IL-10 receptor. Once phosphorylated, STAT.

Overview of molecular JAK signaling.

Presentation transcript:

A Case Study Of A Man With Leukemia

A Chromosomal Translocation is Discovered

PDGFR-beta null mutants are embryonically lethal

PDGFR alpha and beta have different downstream consequences Angiogenesis Lymphocytes Metabolism

The PDGF receptor can activate many Different Pathways

The ETV6-PDGFRB fusion causes constitutive dimerization

Chronic Myelomonocytic Leukemia (CMML) Is a Cancer of the Monocytes

Sources main.pdf?_tid=a610a68e-95bd-11e2-a4ae aab0f01&acdnat= _56d0ab4e796e33281e0ce6e8 1475c3b main.pdf?_tid=a610a68e-95bd-11e2-a4ae aab0f01&acdnat= _56d0ab4e796e33281e0ce6e8 1475c3b2 mpd/HealthProfessional/page2 mpd/HealthProfessional/page # 378# chronicmyelomonocyticcmml/detailedguide/leukemia-chronic- myelomonocytic-diagnosed chronicmyelomonocyticcmml/detailedguide/leukemia-chronic- myelomonocytic-diagnosed