Microangiopathic hemolytic anemia. TTP reticulocytes.

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Presentation transcript:

microangiopathic hemolytic anemia

TTP

reticulocytes

Polychromasia

Autoimmune hemolytic anemia

Target Cells Increased surface to volume ratio Actually shaped like a bell (3D) Target cells are always hypochromic Excess membrane cholesterol and phospholipid Decreased osmotic fragility

Hemoglobin C disease Liver disease Iron deficiency Any hemoglobin abnormality Post splenectomy Target Cells

Target Cells (Codocytes)

Target Cells

10 y/o boy of Italian descent Diagnosis : Beta thalassemia major Homozygous beta 0 thalassemia Comment : beta 0 = beta gene producing no beta chains no beta chains and hence no Hb A. untreated he has about 95% Hb F (remainder being Hb A 2 ) Treatment : Transfusion to maintain hemoglobin level; Chelation therapy to remove excess iron present due to hemolysis and transfusions. Bone marrow transplantation is treatment of choice

Case 2 Howell Jolly Body Sickle cell Erythroblast

Sickle cells (Drepanocytes)

Sickle Cells