Hemophilia Jessica Pinto Ben Hughes Sai Mandalapu February 1, 2010 Period 2

Hemophilia… What’s That? Hemophilia is spontaneous bleeding Bleeding can occur from: – Stress – Mild or greater trauma (sports, etc.) – Before or after surgery Symptoms: – Blood clotting improperly, if at all. – Easily recognizable in childhood It was considered the “royal disease” because Queen Victoria had it and passed it through her family; the Russian royal family at the time also had it.

What chromosome is your disorder located on? It is contracted/passed down through the X-chromosome.

Mode of Inheritance It is passed through the X-chromosome. Men have it, and are affected by it (XY) Women are carriers (XX)

Alleles? Every person has two alleles per gene. Dominant alleles are represented by “big” letters. Recessive genes are represented by “little” letters.

Punnet Square GG Gggg Gg Dark Green: Homozygous Dominant Green-Yellow: Heterozygous Dominant Yellow: Homozygous Recessive G G g g

Punnet Squares In this punnet square, the outcome would be, A son would be affected with hemophilia, two daughters Would be carriers and a boy would be a carrier.

Punnet Squares GGGg ggGg A “Big G” represents the dominant allele, Green. A “Little g” represents the recessive allele, Yellow. g G g G

Probability GGGg gg The probability of this punnet square, is that one of the children is affected with hemophilia, depending on the gender of the child, one of them would have it and the other would only be a carrier, and the final child would only be a carrier. G G g g