Dek Woolfson, Biological Sciences, Sussex Biomolecular Machines Dek Woolfson University of Sussex.

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Presentation transcript:

Dek Woolfson, Biological Sciences, Sussex Biomolecular Machines Dek Woolfson University of Sussex

Dek Woolfson, Biological Sciences, Sussex

Transcription: getting from DNA to RNA

Dek Woolfson, Biological Sciences, Sussex Switching Genes On: Transcription Factors ≈2,300 atoms

Dek Woolfson, Biological Sciences, Sussex Mad Max

Dek Woolfson, Biological Sciences, Sussex Translation: getting from RNA to protein

Dek Woolfson, Biological Sciences, Sussex Making Proteins: Translation on the Ribosome

Dek Woolfson, Biological Sciences, Sussex Protein Folding: getting proteins into shape

Dek Woolfson, Biological Sciences, Sussex Folding Proteins: The GroE Chaperone

Dek Woolfson, Biological Sciences, Sussex doing everything...

Dek Woolfson, Biological Sciences, Sussex Sticky Molecules: EPO ≈3,500 atoms

Dek Woolfson, Biological Sciences, Sussex Dynamic Molecules: Haemoglobin ≈4,400 atoms

Dek Woolfson, Biological Sciences, Sussex Protein Misfolding: proteins behaving badly

Dek Woolfson, Biological Sciences, Sussex Prions & Amyloid

Dek Woolfson, Biological Sciences, Sussex Garbage Disposal: getting rid of unwanted proteins

Dek Woolfson, Biological Sciences, Sussex Recycling Proteins: The Proteasome ≈56,400 atoms

Dek Woolfson, Biological Sciences, Sussex

The Proteasome as a molecular ruler

Dek Woolfson, Biological Sciences, Sussex The Grim Reaper: ubiquitin

Dek Woolfson, Biological Sciences, Sussex ≈600 atoms

Dek Woolfson, Biological Sciences, Sussex

Finding the Energy: How ATP is made.

Dek Woolfson, Biological Sciences, Sussex The F1F0 Complex

Dek Woolfson, Biological Sciences, Sussex The F1 ATPase ≈23,000 atoms

Dek Woolfson, Biological Sciences, Sussex The  -subunit acts as a crankshaft

Dek Woolfson, Biological Sciences, Sussex Rotary Catalysis

Dek Woolfson, Biological Sciences, Sussex The F0 component is in the membrane and acts as a molecular turbine

Dek Woolfson, Biological Sciences, Sussex There’s plenty to do: human karyotype

Dek Woolfson, Biological Sciences, Sussex